Cardiology Today

Welcome to Cardiology Today – Recorded April 14, 2026. This episode summarizes 5 key cardiology studies on topics like femoral venous puncture and catheter manipulation. Key takeaway: Left Bundle Pacing Challenges BiVP for CRT. Article Links: Article 1: Ultrasound-guided vs conventional venous puncture for atrial fibrillation ablation: the ULYSSES trial. (European heart journal) Article 2: Left bundle branch area vs biventricular pacing for cardiac resynchronization therapy: the LEFT-BUNDLE-CRT trial. (European heart journal) Article 3: Mavacamten Versus Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: An Echocardiography-Derived Pressure-Volume Analysis. (Circulation. Heart failure) Article 4: Device-Related Adverse Events and Outcomes in Patients With Temporary Mechanical Circulatory Support Placed at Referral Centers Versus Cardiogenic Shock Hub Centers: An Observational Analysis. (Circulation. Heart failure) Article 5: Characterization of a successful transseptal access with an electrified guidewire: An ex vivo ovine study. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/left-bundle-pacing-challenges-bivp-for-crt-04-14-26/ Featured Articles Article 1: Ultrasound-guided vs conventional venous puncture for atrial fibrillation ablation: the ULYSSES trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41979041 Summary: The ULYSSES trial confirmed that vascular access site complications are the most common procedure-related adverse events during atrial fibrillation catheter ablation. This study directly compared an ultrasound-guided femoral venous puncture strategy with a conventional approach. The multicenter trial evaluated the efficacy of each technique in reducing complications in patients undergoing atrial fibrillation or left atrial tachycardia catheter ablation. The investigation’s findings provided a critical evidence base for optimizing patient safety during these procedures. Article 2: Left bundle branch area vs biventricular pacing for cardiac resynchronization therapy: the LEFT-BUNDLE-CRT trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41978340 Summary: Conduction system pacing has emerged as an alternative to biventricular pacing for cardiac resynchronization therapy. The LEFT-BUNDLE-CRT trial directly compared left-bundle branch area pacing to biventricular pacing. This multicenter, randomized, non-inferiority study provided a comprehensive evaluation of their comparative effectiveness in patients eligible for cardiac resynchronization therapy and left-bundle branch block. The study’s results established the non-inferiority profile of left-bundle branch area pacing against biventricular pacing for this patient population. Article 3: Mavacamten Versus Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: An Echocardiography-Derived Pressure-Volume Analysis. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41969098 Summary: Obstructive hypertrophic cardiomyopathy is characterized by left ventricular outflow tract obstruction, which increases afterload and activates the Anrep response of hyperdynamic systole. This study directly compared the effects of the myosin inhibitor mavacamten to alcohol septal ablation. Researchers evaluated whether mavacamten reverses this hyperdynamic state, contrasting its impacts with the anatomic relief from alcohol septal ablation in 36 patients. The investigation’s echocardiography-derived pressure-volume analysis clarified the differential physiological effects of these two therapeutic approaches. Article 4: Device-Related Adverse Events and Outcomes in Patients With Temporary Mechanical Circulatory Support Placed at Referral Centers Versus Cardiogenic Shock Hub Centers: An Observational Analysis. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41969084 Summary: Temporary...

Welcome to Cardiology Today – Recorded April 14, 2026. This episode summarizes 5 key cardiology studies on topics like aspirin and left bundle branch block. Key takeaway: Time-Varying Data Boosts Transplant Risk Accuracy. Article Links: Article 1: Endovascular Therapy for Post-Thrombotic Syndrome – A Randomized Trial. (The New England journal of medicine) Article 2: Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics. (Circulation) Article 3: Timing is everything: Using time-varying binary indicators for evaluating post-transplant risk factors. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Subclinical atrial fibrillation and the risk of heart failure: insights from ARTESiA. (European journal of heart failure) Article 5: Dyssynchronous heart failure: mitochondrial distribution and functions mirror regional workload and energy demand in a large-animal model of ventricular desynchronization. (European journal of heart failure) Full episode page: https://podcast.explainheart.com/podcast/time-varying-data-boosts-transplant-risk-accuracy-04-14-26/ Featured Articles Article 1: Endovascular Therapy for Post-Thrombotic Syndrome – A Randomized Trial. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41972998 Summary: This randomized trial evaluated endovascular therapy, specifically iliac-vein stent placement, for patients with moderate or severe post-thrombotic syndrome linked to iliac-vein obstruction. The study included 225 patients who received either endovascular therapy or enhanced conventional management, addressing the critical clinical issue of improving quality of life. This trial focused on whether the intervention reduced symptom severity for patients severely affected by post-thrombotic syndrome. Article 2: Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41969103 Summary: This study developed a new strategy using intersectional genetics for cell type-specific targeting of smooth muscle cell populations. This refined approach effectively overcomes limitations of existing Cre/loxP recombination systems that previously showed off-target activity outside the smooth muscle cell lineage. The new method precisely distinguishes among arterial smooth muscle cells, venous smooth muscle cells, and non-vascular smooth muscle cells. This capability is essential for characterizing the distinct roles of smooth muscle cells in various organs and diseases. Article 3: Timing is everything: Using time-varying binary indicators for evaluating post-transplant risk factors. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41974389 Summary: This study demonstrated that incorporating a time-varying binary indicator in a Cox model correctly analyzes post-transplant risk factors. Traditional methods, which treat risk factors as fixed at the time of transplantation, produce inaccurate effect estimates due to immortal time bias. Using infection-related hospitalizations after heart transplantation as an example, this refined approach properly aligns the timing of exposure with survival follow-up. This methodology yields more credible and accurate effect estimates for risk factors emerging after transplantation. Article 4: Subclinical atrial fibrillation and the risk of heart failure: insights from ARTESiA. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41973801 Summary: The ARTESiA (Apixaban for the Reduction of Thromboembolism in Patients with Device-Detected Subclinical Atrial Fibrillation) trial, involving 3986 patients, compared apixaban with aspirin for...

Welcome to Cardiology Today – Recorded April 13, 2026. This episode summarizes 5 key cardiology studies on topics like ischemic stroke and prehospital delay. Key takeaway: Salusin-Alpha Restores Vessels in Pulmonary Hypertension. Article Links: Article 1: Salusin-α Restores Vascular Relaxation and Remodeling in Pulmonary Hypertension. (Hypertension (Dallas, Tex. : 1979)) Article 2: Endothelial Senescence Drives Deleterious Endothelial-Adipocyte Cross-Talk in Patients With Heart Failure and Type 2 Diabetes. (JACC. Basic to translational science) Article 3: Kinetics of Technetium-Labeled Cardiac Amyloid Radionuclide Imaging. (Circulation. Cardiovascular imaging) Article 4: Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Analysis of the TEMPO-2 Trial. (Stroke) Article 5: Cost-Effectiveness of Prehospital Delay Reduction Versus Primary Stroke Prevention in US Adults With Type 2 Diabetes. (Stroke) Full episode page: https://podcast.explainheart.com/podcast/salusin-alpha-restores-vessels-in-pulmonary-hypertension-04-13-26/ Featured Articles Article 1: Salusin-α Restores Vascular Relaxation and Remodeling in Pulmonary Hypertension. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41958393 Summary: This study demonstrated that salusin-alpha restored vascular relaxation and reversed vascular remodeling in pulmonary hypertension. Researchers found these effects by assessing pulmonary artery relaxation using isometric tension recording in isolated rat pulmonary arteries. They quantified reductions in pulmonary artery remodeling through histological morphometric analysis. The data indicated that salusin-alpha significantly alleviated the progressive increase in pulmonary arterial resistance characteristic of pulmonary hypertension. Article 2: Endothelial Senescence Drives Deleterious Endothelial-Adipocyte Cross-Talk in Patients With Heart Failure and Type 2 Diabetes. Journal: JACC. Basic to translational science PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967191 Summary: Microvascular endothelial cells (MVECs) from subcutaneous adipose tissue of patients with type two diabetes mellitus and heart failure exhibited a senescent phenotype. These senescent cells displayed elevated senescence-associated secretory phenotype markers, reduced adenosine triphosphate production, and impaired angiogenic and proliferative capacities. When cocultured with healthy adipocytes, these senescent M. V. E. C. s drove adverse cross-talk, inducing a proinflammatory adipocyte phenotype with increased interleukin-6 expression. This research revealed how endothelial senescence contributes to chronic inflammation in this high-risk patient population. Article 3: Kinetics of Technetium-Labeled Cardiac Amyloid Radionuclide Imaging. Journal: Circulation. Cardiovascular imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41961986 Summary: This study characterized the tracer kinetics of technetium-labeled bone-avid tracers used for diagnosing transthyretin cardiac amyloidosis. Researchers defined these kinetics using quantitative single-photon emission computed tomography with computed tomography in 24 subjects evaluated for the condition. The findings established the kinetic profile of these diagnostic agents. The study also addressed the use of hydroxymethylene diphosphonate as an alternative to technetium-99m pyrophosphate due to supply shortages, noting the limited comparative kinetic data available. Article 4: Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Analysis of the TEMPO-2 Trial. Journal: Stroke PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41958392 Summary: This secondary analysis of the TEMPO-2 multicenter, randomized trial evaluated specific intracranial hemorrhage patterns and their impact on functional outcomes in patients with minor ischemic stroke. The study identified distinct predictors associated with intracranial hemorrhage within this patient...

Welcome to Cardiology Today – Recorded April 13, 2026. This episode summarizes 5 key cardiology studies on topics like sex differences and adverse clinical outcomes. Key takeaway: CKM Syndrome Shapes Atrial Fibrillation Outcomes. Article Links: Article 1: Long-Term Outcomes of Stent-Based Pulmonary Angioplasty for Isolated Peripheral Pulmonary Artery Stenosis. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Plasma Protein Profiles in Different Heart Failure Phenotypes. (ESC heart failure) Article 3: Cardiovascular-kidney-metabolic syndrome and atrial fibrillation: Insights from 2 real-world prospective registries across Europe and East Asia. (Heart rhythm) Article 4: Sex difference in clinically suspected immune checkpoint inhibitor-related myocarditis: a single-institute retrospective study with seven-year follow-up. (International journal of cardiology) Article 5: Plasma Protein Profiles in Different Heart Failure Phenotypes. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/ckm-syndrome-shapes-atrial-fibrillation-outcomes-04-13-26/ Featured Articles Article 1: Long-Term Outcomes of Stent-Based Pulmonary Angioplasty for Isolated Peripheral Pulmonary Artery Stenosis. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967784 Summary: This single-center retrospective study included 23 adults with isolated peripheral pulmonary artery stenosis who received stent-based angioplasty between 2007 and 2024. The study characterized the long-term durability and the incidence and determinants of in-stent restenosis. It also observed changes in patient hemodynamics and six-minute walk distance. This research provides insights into the outcomes of stent-based angioplasty for this rare condition. Article 2: Plasma Protein Profiles in Different Heart Failure Phenotypes. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967491 Summary: This study analyzed data from 50765 U. K. Biobank participants to characterize plasma protein profiles. It examined three distinct heart failure phenotypes: heart failure with preceding myocardial infarction, heart failure with preceding atrial fibrillation, and heart failure without either preceding condition. The analysis was conducted to understand the unique protein signatures across these different heart failure presentations and potentially identify a common protein profile. Article 3: Cardiovascular-kidney-metabolic syndrome and atrial fibrillation: Insights from 2 real-world prospective registries across Europe and East Asia. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41966525 Summary: This study evaluated the association between cardiovascular-kidney-metabolic syndrome stages and adverse clinical outcomes in patients with atrial fibrillation. It included patients from the E. U. R. O. bservational Research Programme Atrial Fibrillation General Long-Term Registry and the K. A. F. Registry, representing real-world populations across Europe and East Asia. The research characterized the clinical impact of cardiovascular-kidney-metabolic syndrome in atrial fibrillation patients by analyzing data from these prospective registries. Article 4: Sex difference in clinically suspected immune checkpoint inhibitor-related myocarditis: a single-institute retrospective study with seven-year follow-up. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967772 Summary: This retrospective study characterized sex differences in clinically suspected immune checkpoint inhibitor-related myocarditis over a seven-year follow-up period. It included patients diagnosed at a single institute between 2018 and 2024. The research analyzed baseline characteristics,...

Welcome to Cardiology Today – Recorded April 12, 2026. This episode summarizes 5 key cardiology studies on topics like pediatric cardiology and morbidity. Key takeaway: Mycn Promotes Heart Protection Post M.I.. Article Links: Article 1: Patient-Surgeon Sex Concordance and Clinical Outcomes After Adult Cardiac Surgery. (Journal of the American Heart Association) Article 2: Increased Risk of Disabilities in Children and Adolescents With Congenital Heart Disease of Any Severity. (Journal of the American Heart Association) Article 3: Correlates and Prognostic Value of Serial N-Terminal Pro-B-Type Natriuretic Peptide Assay in Congenitally Corrected Transposition of the Great Arteries. (Journal of the American Heart Association) Article 4: Long-Term Outcomes With Class 1C Antiarrhythmic Drug Use in Atrial Fibrillation. (Journal of the American Heart Association) Article 5: Mycn Reactivates the Cell Cycle in Adult Cardiomyocytes and Promotes Cardioprotection in Myocardial Infarction. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/mycn-promotes-heart-protection-post-m-i-04-12-26/ Featured Articles Article 1: Patient-Surgeon Sex Concordance and Clinical Outcomes After Adult Cardiac Surgery. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954068 Summary: This large cohort study provided a comprehensive characterization of patient-surgeon sex concordance in relation to clinical outcomes following adult cardiac surgery. The research documented data from 223065 Medicare beneficiaries who underwent coronary artery bypass grafting, surgical aortic valve replacement, or proximal aortic surgery. The study’s analysis focused on composite outcomes of mortality and morbidity, including myocardial infarction, stroke, and all-cause readmission, stratified by surgeon and patient sex. These findings contribute crucial information for understanding potential sex-based differences in cardiac surgical care. Article 2: Increased Risk of Disabilities in Children and Adolescents With Congenital Heart Disease of Any Severity. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954067 Summary: This retrospective data-linkage study found an increased risk of disabilities in children and adolescents diagnosed with congenital heart disease of any severity. The research revealed a higher prevalence of overall and specific disability service use within this patient group compared to matched controls and siblings. These findings highlight a significant burden of disabilities across all severities of congenital heart disease in pediatric patients. The study provides crucial information for long-term care planning and resource allocation for this population. Article 3: Correlates and Prognostic Value of Serial N-Terminal Pro-B-Type Natriuretic Peptide Assay in Congenitally Corrected Transposition of the Great Arteries. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954066 Summary: This study established the correlates and confirmed the prognostic value of serial N-terminal pro-B-type natriuretic peptide assays in adults with congenitally corrected transposition of the great arteries. The research provided specific data on the role of these measurements for heart failure risk stratification in this distinct patient population. The findings confirm N-terminal pro-B-type natriuretic peptide as a relevant cardiovascular biomarker, addressing previously limited data for this group. This offers important insights for clinical monitoring and management of these adults. Article 4: Long-Term Outcomes With Class 1C Antiarrhythmic Drug Use in Atrial Fibrillation. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954064 Summary: This large study characterized the long-term outcomes associated with class...

Welcome to Cardiology Today – Recorded April 11, 2026. This episode summarizes 5 key cardiology studies on topics like mineralocorticoid receptor antagonist and Kidney Failure Risk Equation. Key takeaway: Catheter Ablation Improves RV-PA Coupling in AF. Article Links: Article 1: An integrated Biobank in the Swedish Heart Failure Registry – clinomics, proteomics, transcriptomics and genomics. (ESC heart failure) Article 2: Spironolactone, Early Acute eGFR Changes, and Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction: Insights from TOPCAT Americas. (European journal of heart failure) Article 3: Kidney Failure Risk Equation and Risk of Kidney and Cardiovascular Outcomes in Patients with Heart Failure with Reduced Ejection Fraction: Insights from PARADIGM-HF. (European journal of heart failure) Article 4: Perceived Inadequate Neighborhood Food Shopping and Cardiovascular Disease Risk: The Multi-Ethnic Study of Atherosclerosis. (Journal of the American Heart Association) Article 5: Right Ventricular-Pulmonary Artery Coupling in Patients With Atrial Fibrillation and Changes After Catheter Ablation. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/catheter-ablation-improves-rv-pa-coupling-in-af-04-11-26/ Featured Articles Article 1: An integrated Biobank in the Swedish Heart Failure Registry – clinomics, proteomics, transcriptomics and genomics. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41961636 Summary: The Swedish Heart Failure Registry established a comprehensive integrated biobank, systematically collecting blood and urine samples from heart failure patients across nine hospitals. This resource captures extensive clinomic, proteomic, transcriptomic, and genomic data, coupled with clinical and diagnostic characteristics. The integrated biobank provides a robust platform for advanced research to identify novel biomarkers and understand disease mechanisms in heart failure. Article 2: Spironolactone, Early Acute eGFR Changes, and Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction: Insights from TOPCAT Americas. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41961632 Summary: A post-hoc analysis of 1648 patients from the TOPCAT Americas trial revealed insights into early acute changes in estimated glomerular filtration rate following spironolactone initiation in Heart Failure with Preserved Ejection Fraction (H. F. pEF). The study characterized the frequency and prognostic relevance of these kidney function alterations. The data elucidated implications of these changes for clinical outcomes in patients receiving mineralocorticoid receptor antagonists, providing guidance for therapeutic management. Article 3: Kidney Failure Risk Equation and Risk of Kidney and Cardiovascular Outcomes in Patients with Heart Failure with Reduced Ejection Fraction: Insights from PARADIGM-HF. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41961588 Summary: This study demonstrated the association of the Kidney Failure Risk Equation (KFRE) score with kidney and cardiovascular outcomes in patients with Heart Failure with Reduced Ejection Fraction (H. F. rEF) and chronic kidney disease (C. K. D.). Analyzing data from the PARADIGM-HF trial, the 2- and 5-year KFRE score, which includes urine albumin-creatinine ratio (UACR), age, sex, and estimated glomerular filtration rate (eGFR), predicted risks for both kidney failure and cardiovascular events. The findings support the clinical utility of the KFRE in this heart failure population for prognostication and risk stratification, extending its recommended use beyond general chronic kidney disease. Article 4: Perceived Inadequate Neighborhood Food Shopping and Cardiovascular Disease Risk: The Multi-Ethnic Study of Atherosclerosis. Journal: Journal of the American...

Welcome to Cardiology Today – Recorded April 11, 2026. This episode summarizes 5 key cardiology studies on topics like Transplantation and Procedural futility. Key takeaway: ML Model Predicts TAVR Mortality, Futility. Article Links: Article 1: How Contemporary Living Kidney Donor Transplants Compare to pre-Pandemic Trends: An Interrupted Time Series Analysis. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 2: Food Supplementation in Patients Hospitalized for Heart Failure: A Randomized Clinical Trial. (JAMA cardiology) Article 3: Risk factor profiles and haemodynamic progression in aortic stenosis: a retrospective population-based study. (Heart (British Cardiac Society)) Article 4: Subphenogroups of acute heart failure with preserved ejection fraction: comprehensive proteomics and pathway analysis. (Heart (British Cardiac Society)) Article 5: Parsimonious machine learning model to predict 1-year mortality and procedural futility after transcatheter aortic valve replacement. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/ml-model-predicts-tavr-mortality-futility-04-11-26/ Featured Articles Article 1: How Contemporary Living Kidney Donor Transplants Compare to pre-Pandemic Trends: An Interrupted Time Series Analysis. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41962844 Summary: Living donor kidney transplants are crucial for patients needing access to kidney transplantation. Little research had previously quantified living donor kidney transplant behaviors following the COVID-19 pandemic. This study analyzed national Scientific Registry of Transplant Recipients and Census data to characterize contemporary donor and recipient patterns. This investigation established foundational epidemiological context for understanding post-pandemic living donor kidney transplant trends. Article 2: Food Supplementation in Patients Hospitalized for Heart Failure: A Randomized Clinical Trial. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41949846 Summary: Low-quality dietary intake is associated with adverse heart failure outcomes. The evidence for food-as-medicine interventions in this patient population remained limited. Researchers conducted a randomized clinical trial to assess the feasibility of providing food supplementation with medically tailored meals or fresh produce. This trial provides foundational insights into the potential clinical associations of such interventions for recently hospitalized heart failure patients. Article 3: Risk factor profiles and haemodynamic progression in aortic stenosis: a retrospective population-based study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41962953 Summary: Aortic stenosis is a progressive disease with significant variability in its progression rate. Current surveillance guidelines do not adequately identify individuals at highest risk for rapid hemodynamic deterioration. This retrospective population-based study assessed aortic stenosis progression rates and factors associated with rapid progression using real-world, longitudinal data. This research provides essential insights for refining risk assessment and improving surveillance strategies in aortic stenosis patients. Article 4: Subphenogroups of acute heart failure with preserved ejection fraction: comprehensive proteomics and pathway analysis. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40750341 Summary: The heterogeneity of heart failure with preserved ejection fraction (H. F. pEF) presents significant challenges for treatment development. This study characterized distinct subphenogroups of H. F. pEF...

Welcome to Cardiology Today – Recorded April 10, 2026. This episode summarizes 5 key cardiology studies on topics like blood pressure control and trophoblast differentiation. Key takeaway: Nurses Cut Stroke BP with Phone Intervention. Article Links: Article 1: Mechanical Thrombectomy and Catheter-Directed Thrombolysis in Acute Pulmonary Embolism: Trends and Practice Patterns in the PERT Consortium Registry (2016-2024). (Journal of the American College of Cardiology) Article 2: Defective Trophoblast Differentiation, Endothelial Dysfunction, and Immune Dysregulation in Preeclampsia Coalesce on a Placental VGLL3-Centered Gene Network. (Circulation) Article 3: Phone-Based Intervention Under Nurse Guidance for Control of Hypertension After Stroke: A Randomized Multicenter Phase 3 Trial in Ghana. (Circulation) Article 4: Cascade genetic screening in families with hereditary transthyretin amyloidosis: diagnostic and prognostic impact. (European heart journal) Article 5: Burst Exercise Stress Testing in Catecholaminergic Polymorphic Ventricular Tachycardia. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/nurses-cut-stroke-bp-with-phone-intervention-04-10-26/ Featured Articles Article 1: Mechanical Thrombectomy and Catheter-Directed Thrombolysis in Acute Pulmonary Embolism: Trends and Practice Patterns in the PERT Consortium Registry (2016-2024). Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41739022 Summary: The PERT Consortium Registry analyzed trends in the use of catheter-directed thrombolysis and mechanical thrombectomy for acute pulmonary embolism between 2016 and 2024. This registry provided real-world data on the diffusion of these catheter-based interventions, including patient and imaging characteristics. It further documented institutional variation in the application of catheter-directed thrombolysis and mechanical thrombectomy in clinical practice. The findings offer concrete insights into contemporary management strategies for acute pulmonary embolism. Article 2: Defective Trophoblast Differentiation, Endothelial Dysfunction, and Immune Dysregulation in Preeclampsia Coalesce on a Placental VGLL3-Centered Gene Network. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41953989 Summary: Human single-cell and spatial analyses, along with in vitro and in vivo models, demonstrated that VGLL3, a transcription coregulator in the Hippo pathway, is upregulated in preeclamptic placentas. This upregulation of VGLL3 promotes immune dysregulation, defective trophoblast differentiation, and endothelial dysfunction. The data revealed that these pathological processes coalesce on a placental VGLL3-centered gene network. This identifies VGLL3 as a key orchestrator of molecular events underlying preeclampsia development. Article 3: Phone-Based Intervention Under Nurse Guidance for Control of Hypertension After Stroke: A Randomized Multicenter Phase 3 Trial in Ghana. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41953982 Summary: The PINGS, Phone-Based Intervention Under Nurse Guidance for Control of Hypertension After Stroke, trial was a randomized multicenter phase three study conducted in Ghana. This trial found that a phone-based intervention, led by nurses, effectively improved blood pressure control among patients with recent stroke. The study demonstrated this intervention as a pragmatic and scalable strategy to address the burden of stroke in resource-limited African settings. These results provide a clinically significant approach for managing hypertension after stroke in low-income countries. Article 4: Cascade genetic screening in families with hereditary transthyretin amyloidosis: diagnostic and prognostic impact. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41955077 Summary: This retrospective study analyzed 967 individuals from 431 families with...

Welcome to Cardiology Today – Recorded April 09, 2026. This episode summarizes 5 key cardiology studies on topics like atherosclerotic cardiovascular disease and heart failure with preserved ejection fraction. Key takeaway: RBM20 Gene Links to Arrhythmogenic Cardiomyopathy. Article Links: Article 1: Multifaceted Strategies for Hypertension Control in Low-Income Patients. (The New England journal of medicine) Article 2: Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease. (The New England journal of medicine) Article 3: Trajectories and outcomes in patients with cardiogenic shock receiving heart replacement therapies. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Performance of the HFpEF-ABA, H2FPEF, and HFA-PEFF Algorithms in HFpEF: A Participant-Level Pooled Analysis of Randomized Clinical Trials. (Journal of cardiac failure) Article 5: RBM20 Truncating Variants and Human Cardiomyopathy. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/rbm20-gene-links-to-arrhythmogenic-cardiomyopathy-04-09-26/ Featured Articles Article 1: Multifaceted Strategies for Hypertension Control in Low-Income Patients. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41950472 Summary: Uncontrolled hypertension disproportionately impacts populations with substantial health disparities, underscoring the importance of targeted interventions. Multifaceted, team-based strategies represent a key therapeutic approach for hypertension control in low-income patients. These strategies involve comprehensive implementation within federally qualified health center clinics. Such approaches are critical for addressing health inequities in communities with high rates of uncontrolled hypertension. Article 2: Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910315 Summary: Intensive low-density lipoprotein cholesterol targeting is a primary therapeutic approach rigorously evaluated for secondary prevention in patients with atherosclerotic cardiovascular disease. A trial compared targeting low-density lipoprotein cholesterol to less than 55 mg per deciliter against a target of 70 to 100 mg per deciliter. This direct comparison clarifies optimal lipid management strategies and informs guideline recommendations. The evaluation provides essential insights into reducing cardiovascular risk through aggressive low-density lipoprotein cholesterol reduction. Article 3: Trajectories and outcomes in patients with cardiogenic shock receiving heart replacement therapies. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41951134 Summary: Understanding trajectories and outcomes in patients with cardiogenic shock receiving heart replacement therapies is a critical area of clinical investigation. Patient severity in cardiogenic shock is characterized using Society for Cardiovascular Angiography and Interventions stages, machine learning-derived phenotypes, and the Comorbidity Risk Index. These comprehensive tools offer advanced stratification to guide management. The comparison of patients receiving heart replacement therapies versus no therapy during index hospitalization provides crucial insights for optimizing patient care. Article 4: Performance of the HFpEF-ABA, H2FPEF, and HFA-PEFF Algorithms in HFpEF: A Participant-Level Pooled Analysis of Randomized Clinical Trials. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41950988 Summary: Multiple algorithms, including HFpEF-ABA, H₂FPEF, and HFA-PEFF, provide valuable tools for improving diagnosis and risk stratification in heart failure...

Welcome to Cardiology Today – Recorded April 08, 2026. This episode summarizes 5 key cardiology studies on topics like hypertensive heart failure and COVID-19. Key takeaway: Early PCSK9 Inhibitors Boost Stroke Outcomes. Article Links: Article 1: Eclampsia and early readmission for cardiovascular disease. (European heart journal) Article 2: Checkpoint kinase Wee1 activation drives inflammation and hypertrophy through the protein kinase B/phosphoinositide 3-kinases-nuclear factor κB pathway in cardiomyocytes. (European heart journal) Article 3: Residential Greenness and Risk of Coronary Artery Disease Following COVID-19: A Nationwide Cohort Study in South Korea. (Journal of the American Heart Association) Article 4: Assessing the Cost Effectiveness of an Incremental Lipid-Lowering Therapy Approach After Coronary Artery Bypass Grafting Using Nationwide Data. (Journal of the American Heart Association) Article 5: Early PCSK9 Inhibitor Use Correlates With Improved Outcomes in Patients With Acute Stroke Receiving Endovascular Therapy. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/early-pcsk9-inhibitors-boost-stroke-outcomes-04-08-26/ Featured Articles Article 1: Eclampsia and early readmission for cardiovascular disease. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40689758 Summary: This study focused on determining whether patients with eclampsia have an increased risk for readmission due to cardiovascular disease within the first year after delivery. Researchers identified cardiovascular disease events from the Nationwide Readmissions Database between 2010 and 2018. This investigation highlights a crucial period for potential cardiovascular complications among patients following eclampsia, underscoring the importance of post-partum surveillance. Article 2: Checkpoint kinase Wee1 activation drives inflammation and hypertrophy through the protein kinase B/phosphoinositide 3-kinases-nuclear factor κB pathway in cardiomyocytes. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40396291 Summary: This study identified Wee1 G2 checkpoint kinase as activated and involved in hypertensive heart failure. Researchers found that Wee1 drives inflammation and hypertrophy through the protein kinase B / phosphoinositide 3-kinases – nuclear factor kappa B pathway in cardiomyocytes. This mechanism provides a specific molecular target for developing new therapeutic strategies against hypertensive heart failure. Article 3: Residential Greenness and Risk of Coronary Artery Disease Following COVID-19: A Nationwide Cohort Study in South Korea. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944181 Summary: This nationwide cohort study in South Korea explored the association between residential greenness and incident coronary artery disease following COVID-19. The investigation revealed that residential greenness is relevant to ischemic heart disease risk after severe acute respiratory syndrome coronavirus two infection, an area previously unclear. This highlights the potential impact of environmental factors on post-COVID-19 cardiovascular health. Article 4: Assessing the Cost Effectiveness of an Incremental Lipid-Lowering Therapy Approach After Coronary Artery Bypass Grafting Using Nationwide Data. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944180 Summary: This study addressed the cost-effectiveness of an incremental lipid-lowering therapy approach after coronary artery bypass grafting, acknowledging the cost limitations of PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors. Researchers conducted mathematical modeling on a nationwide cohort of United States veterans to understand the need for these expensive drugs. The findings contribute to strategies for optimizing lipid-lowering therapy...

Welcome to Cardiology Today – Recorded April 08, 2026. This episode summarizes 5 key cardiology studies on topics like Heart Failure with Preserved Ejection Fraction and galectin three. Key takeaway: Olfactory Receptor Halts Platelet Clotting. Article Links: Article 1: Mir147 Limits the Contribution of Non-Foamy Macrophages to Atherosclerosis. (Circulation) Article 2: Multi-Organ Physiologic Deficits During Exercise Identify Clinical and Molecular Predisposition to Heart Failure with Preserved Ejection Fraction. (Circulation) Article 3: Olfactory Receptor Activation Reduces Platelet Reactivity and Arterial Thrombosis Through Actin Cytoskeleton Remodeling. (Circulation) Article 4: Characteristics of Protein Profiling and Biomarkers in Aortic Regurgitation With Heart Failure. (Journal of the American Heart Association) Article 5: Elevated Interleukin-6 Levels in Socioeconomically Disadvantaged Children With Borderline Subclinical Rheumatic Heart Disease in São Paulo, Brazil: A Prospective Cohort Study Highlighting Early Detection and Treatment Opportunities. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/olfactory-receptor-halts-platelet-clotting-04-08-26/ Featured Articles Article 1: Mir147 Limits the Contribution of Non-Foamy Macrophages to Atherosclerosis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944070 Summary: The study found that Mir147 (microRNA 147) limits the contribution of non-foamy macrophages to atherosclerosis by downregulating inflammatory activation. Specifically, Mir147-3p is upregulated by inflammation and functions to reduce inflammatory responses within these macrophages. This mechanism prevents the inflammatory activation of non-foamy macrophages, thereby reducing their role in the progression of atherosclerosis. The findings establish a new regulatory pathway in macrophage biology relevant to atherosclerotic disease. Article 2: Multi-Organ Physiologic Deficits During Exercise Identify Clinical and Molecular Predisposition to Heart Failure with Preserved Ejection Fraction. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944041 Summary: This study found that multi-organ physiologic deficits identified during exercise characterize Heart Failure with Preserved Ejection Fraction (H. F. pEF). The research identified seven specific exercise-related deficits, including reduced peak oxygen uptake and chronotropic incompetence, in patients with this condition. These multi-organ limitations were directly associated with the severity and prognosis of Heart Failure with Preserved Ejection Fraction. The findings establish a link between these exercise deficits and both clinical and molecular predispositions to Heart Failure with Preserved Ejection Fraction. Article 3: Olfactory Receptor Activation Reduces Platelet Reactivity and Arterial Thrombosis Through Actin Cytoskeleton Remodeling. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944007 Summary: The study found that activating the human olfactory receptor 2 L 13 (O. R. 2 L 13) on platelets significantly reduced platelet aggregation in laboratory settings. Activation of O. R. 2 L 13 also provided robust protection against arterial thrombosis in living organisms. This antithrombotic effect occurs through the mechanism of actin cytoskeleton remodeling within the platelets. These findings identify platelet O. R. 2 L 13 activation as a novel and effective strategy for reducing platelet reactivity and preventing arterial thrombosis. Article 4: Characteristics of Protein Profiling and Biomarkers in Aortic Regurgitation With Heart Failure. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944198 Summary: This study identified 23 differentially expressed proteins in patients with severe aortic regurgitation compared to control subjects. Specifically, 7 proteins were upregulated and...

Welcome to Cardiology Today – Recorded April 07, 2026. This episode summarizes 5 key cardiology studies on topics like guideline-directed medical therapy and congenital heart disease. Key takeaway: Telomere Recapping Blocks Heart Failure Mechanism. Article Links: Article 1: Apolipoprotein D, a Novel Ligand for CD36, Is Essential for Blood-Brain Barrier Integrity. (Circulation) Article 2: A Randomized Controlled Trial Comparing Different Programming Strategies of Left Bundle Branch Area Pacing on Left Atrial Volume and Atrial High-Rate Episodes in Patients With Sinus Node Dysfunction. (The American journal of cardiology) Article 3: Telomere recapping prevents pathogenic telomere-to-mitochondrial DNA communication in heart failure. (Cardiovascular research) Article 4: Longitudinal trajectories of secondary mitral regurgitation in non-ischemic dilated cardiomyopathy. (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography) Article 5: Stress, coping, protective factors, and quality of life in parents of infants with CHD: associations with state anxiety. (Cardiology in the young) Full episode page: https://podcast.explainheart.com/podcast/telomere-recapping-blocks-heart-failure-mechanism-04-07-26/ Featured Articles Article 1: Apolipoprotein D, a Novel Ligand for CD36, Is Essential for Blood-Brain Barrier Integrity. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41645912 Summary: D. 36, Is Essential for Blood-Brain Barrier Integrity. This study found that Apolipoprotein D is a novel ligand for C. D. 36 and is essential for maintaining blood-brain barrier integrity. This mechanism is critical because disruption of the blood-brain barrier is a central pathogenic event in many central nervous system disorders. The research identifies a specific molecular pathway governing blood-brain barrier function. This fundamental understanding of blood-brain barrier regulation provides a basis for future therapeutic strategies. Article 2: A Randomized Controlled Trial Comparing Different Programming Strategies of Left Bundle Branch Area Pacing on Left Atrial Volume and Atrial High-Rate Episodes in Patients With Sinus Node Dysfunction. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41942043 Summary: Left bundle branch area pacing is a physiological pacing modality preserving ventricular synchrony. Optimal programming strategies for patients with sinus node dysfunction, particularly those with delayed intrinsic atrioventricular conduction, have remained clinically uncertain. It is understood that minimal ventricular pacing algorithms can permit non-physiological atrioventricular prolongation, which contributes to left atrial remodeling and atrial high-rate episodes. This randomized controlled trial directly compared maximal atrioventricular sequential pacing with minimal ventricular pacing strategies to address these critical clinical outcomes. Article 3: Telomere recapping prevents pathogenic telomere-to-mitochondrial DNA communication in heart failure. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41942104 Summary: N. A. communication in heart failure. This study found that telomere recapping prevents pathogenic communication between telomeres and mitochondrial deoxyribonucleic acid in heart failure. Diseased cardiomyocytes exhibit telomeric shortening, which triggers deoxyribonucleic acid damage responses and leads to mitochondrial dysfunction. This finding demonstrates a novel mechanism to restore myocardial function, addressing the high prevalence and significant mortality of heart failure, where five-year survival remains at fifty percent. Telomere recapping thus represents a promising therapeutic target for improving heart failure outcomes. Article 4: Longitudinal trajectories of secondary mitral regurgitation in non-ischemic dilated cardiomyopathy. Journal: Journal...

Welcome to Cardiology Today – Recorded April 06, 2026. This episode summarizes 5 key cardiology studies on topics like rehabilitation needs and coronary computed tomography angiography. Key takeaway: AI C. C. T. A. Guides Optimal L. L. M. Benefit. Article Links: Article 1: Association Between Functional Status and Cardiac Function in Chronic Heart Failure: Insights from the C-MIC II Trial. (ESC heart failure) Article 2: Association Between Functional Status and Cardiac Function in Chronic Heart Failure: Insights from the C-MIC II Trial. (ESC heart failure) Article 3: Quantitative Coronary Atherosclerotic Plaque Burden From CCTA and the Benefit From Lipid-Lowering Medication. (Circulation. Cardiovascular imaging) Article 4: The inferior vena cava collapsibility index as a non-invasive marker of early haemodynamic changes following atrial septal defect closure. (Cardiology in the young) Article 5: Physical therapy enhances patient care in post-congenital heart surgery clinic. (Cardiology in the young) Full episode page: https://podcast.explainheart.com/podcast/ai-c-c-t-a-guides-optimal-l-l-m-benefit-04-06-26/ Featured Articles Article 1: Association Between Functional Status and Cardiac Function in Chronic Heart Failure: Insights from the C-MIC II Trial. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41941602 Summary: This post hoc analysis from the cardiac microcurrent (C-MIC) two trial highlighted that the precise relationship between changes in cardiac function, functional capacity, and patient-reported health status in chronic Heart Failure remains incompletely defined. The C-MIC two trial evaluated the efficacy and safety of cardiac microcurrent therapy in patients with chronic Heart Failure with Reduced Ejection Fraction receiving optimal guideline-directed medical therapy. This study confirmed the ongoing need for research into how distinct clinical domains reflect treatment response for this patient population. Article 2: Association Between Functional Status and Cardiac Function in Chronic Heart Failure: Insights from the C-MIC II Trial. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41941602 Summary: This post hoc analysis from the cardiac microcurrent (C-MIC) two trial highlighted that the precise relationship between changes in cardiac function, functional capacity, and patient-reported health status in chronic Heart Failure remains incompletely defined. The C-MIC two trial evaluated the efficacy and safety of cardiac microcurrent therapy in patients with chronic Heart Failure with Reduced Ejection Fraction receiving optimal guideline-directed medical therapy. This study confirmed the ongoing need for research into how distinct clinical domains reflect treatment response for this patient population. Article 3: Quantitative Coronary Atherosclerotic Plaque Burden From CCTA and the Benefit From Lipid-Lowering Medication. Journal: Circulation. Cardiovascular imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41937634 Summary: This observational cohort study found that artificial intelligence-guided quantitative coronary computed tomography angiography identified patients who derive outcome benefit from lipid-lowering medication. The study showed that quantification of coronary atherosclerotic plaque burden, specifically percent atheroma volume, serves as a marker for guiding therapy. This demonstrates that advanced imaging can personalize lipid-lowering medication strategies for symptomatic patients with suspected coronary artery disease. Article 4: The inferior vena cava collapsibility index as a non-invasive marker of early haemodynamic changes following atrial septal defect closure. Journal: Cardiology in the young PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41940521 Summary: This retrospective study found that the inferior vena cava collapsibility index serves as a non-invasive marker for early hemodynamic changes following transcatheter...

Welcome to Cardiology Today – Recorded April 06, 2026. This episode summarizes 5 key cardiology studies on topics like heart failure with preserved ejection fraction and coronary artery bypass grafting. Key takeaway: NOBLE Trial’s 10-Year Left Main Data. Article Links: Article 1: Beyond ion channel dysfunction: Integration of the transcriptome and proteome from patient-specific re-engineered cardiac cells, and population-level QT genome-wide association study reveals broad cellular dysfunction. (Heart rhythm) Article 2: Utilization and Outcomes of Dual Antiplatelet Therapy in Patients with Active Cancer Presenting with Acute Myocardial Infarction: A Global Registry Study. (The American journal of cardiology) Article 3: Cardiovascular pharmacotherapy in year in 2025. (European heart journal. Cardiovascular pharmacotherapy) Article 4: Economic Burden Associated with Systemic Inflammation in Patients with HFmrEF/HFpEF. (American heart journal) Article 5: Percutaneous coronary intervention versus coronary artery bypass grafting for unprotected left main stenosis: 10-year final results from the randomised, open-label, non-inferiority NOBLE trial. (Lancet (London, England)) Full episode page: https://podcast.explainheart.com/podcast/noble-trials-10-year-left-main-data-04-06-26/ Featured Articles Article 1: Beyond ion channel dysfunction: Integration of the transcriptome and proteome from patient-specific re-engineered cardiac cells, and population-level QT genome-wide association study reveals broad cellular dysfunction. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41936938 Summary: The study demonstrated broad cellular dysfunction in congenital Long Q. T. syndrome. This finding emerged from integrating transcriptomic and proteomic profiles of patient-derived inducible pluripotent stem cell-derived cardiomyocyte models representing L. Q. T. type one, L. Q. T. type two, and L. Q. T. type three genotypes. The investigation also incorporated population-level Q. T. genome-wide association study data, revealing cellular impairments beyond mere ion channel dysfunction and providing a deeper understanding of the disease’s mechanisms. Article 2: Utilization and Outcomes of Dual Antiplatelet Therapy in Patients with Active Cancer Presenting with Acute Myocardial Infarction: A Global Registry Study. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41936851 Summary: The global registry study characterized the utilization patterns and associated outcomes of dual antiplatelet therapy in patients with active cancer experiencing acute myocardial infarction. The investigation addressed the critical clinical challenge of balancing competing risks of thrombosis and bleeding when selecting optimal therapy in this high-mortality population. It comprehensively analyzed therapy use and outcomes, with all-cause mortality serving as the primary endpoint in these complex patients. Article 3: Cardiovascular pharmacotherapy in year in 2025. Journal: European heart journal. Cardiovascular pharmacotherapy PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41935384 Summary: Significant advances in cardiovascular pharmacotherapy were identified, including the approval of four new drugs: aficamten, etripamil, lerodalcibep, and plozasiran. Additionally, five already approved drugs received label expansions, broadening their therapeutic applications. The review also summarized key findings from major randomized clinical trials that further advanced treatment strategies, collectively addressing the ongoing need for more effective and safer pharmacological interventions across various cardiovascular diseases. Article 4: Economic Burden Associated with Systemic Inflammation in Patients with HFmrEF/HFpEF. Journal: American heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41936927 Summary: This retrospective cohort study characterized the economic burden associated with systemic...

Welcome to Cardiology Today – Recorded April 05, 2026. This episode summarizes 2 key cardiology studies on topics like excitation-contraction coupling and right heart catheterization. Key takeaway: Stroke Volume Index for Pediatric P.A.H. Prognosis. Article Links: Article 1: Long-term genetic Orai1 inhibition modulates excitation-contraction coupling in female adult mouse ventricular cardiomyocytes. (American journal of physiology. Heart and circulatory physiology) Article 2: Clinical Utility of Stroke Volume Index in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension. (Pediatric cardiology) Full episode page: https://podcast.explainheart.com/podcast/stroke-volume-index-for-pediatric-p-a-h-prognosis-04-05-26/ Featured Articles Article 1: Long-term genetic Orai1 inhibition modulates excitation-contraction coupling in female adult mouse ventricular cardiomyocytes. Journal: American journal of physiology. Heart and circulatory physiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41926628 Summary: This study found that long-term genetic inhibition of Orai1, a store-operated calcium channel, modulates excitation-contraction coupling in adult mouse ventricular cardiomyocytes. Using a mouse model expressing a dominant-negative human Orai1R91W mutant, researchers observed elevated intracellular calcium transients and calcium spark amplitudes in female mice compared to wild-type controls. These specific findings demonstrate a sex-specific contribution of Orai1 to cardiac excitation-contraction coupling. This indicates a novel role for Orai1 in cardiac function that varies between sexes. Article 2: Clinical Utility of Stroke Volume Index in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension. Journal: Pediatric cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41925853 Summary: This retrospective study determined the clinical utility of stroke volume index in children with idiopathic and heritable pulmonary arterial hypertension. It assessed the prognostic value of stroke volume index, which was evaluated by right heart catheterization, in 103 pediatric patients. The study found a relationship between stroke volume index and adverse outcomes, specifically lung transplant and cardiac death. These findings establish stroke volume index as a valuable prognostic indicator in this pediatric patient population. Transcript Today’s date is April 05, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Long-term genetic Orai1 inhibition modulates excitation-contraction coupling in female adult mouse ventricular cardiomyocytes. This study found that long-term genetic inhibition of Orai1, a store-operated calcium channel, modulates excitation-contraction coupling in adult mouse ventricular cardiomyocytes. Using a mouse model expressing a dominant-negative human Orai1R91W mutant, researchers observed elevated intracellular calcium transients and calcium spark amplitudes in female mice compared to wild-type controls. These specific findings demonstrate a sex-specific contribution of Orai1 to cardiac excitation-contraction coupling. This indicates a novel role for Orai1 in cardiac function that varies between sexes. Article number two. Clinical Utility of Stroke Volume Index in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension. This retrospective study determined the clinical utility of stroke volume index in children with idiopathic and heritable pulmonary arterial hypertension. It assessed the prognostic value of stroke volume index, which was evaluated by right heart catheterization, in 103 pediatric patients. The study found a relationship between stroke volume index and adverse outcomes, specifically lung transplant and cardiac death. These findings establish stroke volume index as a valuable prognostic indicator in this pediatric patient population. Thank you for listening. Don’t forget to...

Welcome to Cardiology Today – Recorded April 05, 2026. This episode summarizes 5 key cardiology studies on topics like wall thickness heterogeneity and hypertrophic cardiomyopathy. Key takeaway: TCF21 Protects Heart Against Fibrosis. Article Links: Article 1: Mass spectrometric proteome profiling using a deep spectral library reveals homogenization of right and left atrial proteomes in persistent atrial fibrillation patients. (Cardiovascular research) Article 2: Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis. (Cardiovascular research) Article 3: How Accurate Is Inpatient Blood Pressure Measurement? (Hypertension (Dallas, Tex. : 1979)) Article 4: Epicardial-to-Endocardial Activation Gradients and Conduction Block During Atrial Fibrillation in the Human Left Atrial Posterior Wall. (Circulation. Arrhythmia and electrophysiology) Article 5: MRI-derived Wall Thickness Heterogeneity in Hypertrophic Cardiomyopathy and in Carriers of Sarcomeric Gene Mutations. (European heart journal. Cardiovascular Imaging) Full episode page: [EPISODE_URL_PLACEHOLDER] Featured Articles Article 1: Mass spectrometric proteome profiling using a deep spectral library reveals homogenization of right and left atrial proteomes in persistent atrial fibrillation patients. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41928451 Summary: This study revealed a homogenization of the right and left atrial proteomes in patients with persistent atrial fibrillation. Researchers used a proteomic approach to investigate atrial fibrillation-associated remodeling in the right atrium relative to the left atrium. The data showed that protein profiles in both atria become similar during persistent atrial fibrillation. This finding indicates widespread atrial remodeling extending beyond the left atrium in this patient population. Article 2: Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41926244 Summary: Single nucleus R. N. A. sequencing and functional in vivo studies demonstrated that TCF21 acts as a protective regulator in cardiac fibrosis. This research specifically identified TCF21 as a novel cell-specific candidate gene involved in cardiac fibrosis. The study validated the functional impact of TCF21 using both in vitro and in vivo models. These findings offer a significant breakthrough for cardiac fibrosis, an untreatable contributor to mortality in chronic heart disease. Article 3: How Accurate Is Inpatient Blood Pressure Measurement? Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41930396 Summary: Observations were conducted across three noncritical care wards: aged care, acute surgical, and hematology, over a three-week period. The investigation revealed that no existing guidelines for accurate inpatient blood pressure measurement are currently in place. This highlights a critical need for standardized quality techniques in this clinical setting. Article 4: Epicardial-to-Endocardial Activation Gradients and Conduction Block During Atrial Fibrillation in the Human Left Atrial Posterior Wall. Journal: Circulation. Arrhythmia and electrophysiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41930410 Summary: This study characterized endocardial and epicardial left atrial posterior wall activation in humans during atrial fibrillation. Researchers identified epicardial-to-endocardial activation gradients and conduction blocks within the left atrial posterior wall. The findings demonstrated the prevalence of asynchronous endocardial-epicardial conduction in this region for patients with symptomatic nonparoxysmal atrial fibrillation. This research provides crucial insights into three-dimensional myocardial activation patterns during atrial...

Welcome to Cardiology Today – Recorded April 04, 2026. This episode summarizes 5 key cardiology studies on topics like arrhythmia vulnerability and catheter ablation. Key takeaway: Senolytics Prevent Atrial Arrhythmias in Elderly. Article Links: Article 1: Impact of left atrial posterior wall isolation using pulsed-field ablation in patients undergoing repeat catheter ablation for atrial fibrillation. (Heart rhythm) Article 2: Comparison of combined anatomic and functional modeling with purely anatomic assessment in scar-dependent ventricular tachycardia. (Heart rhythm) Article 3: Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits. (Heart rhythm) Article 4: Real-world performance of intrinsic antitachycardia pacing: Primary results from a global prospective postapproval registry study. (Heart rhythm) Article 5: Purkinje and septal substrate modification as a therapeutic option for patients with STEMI and refractory ventricular fibrillation. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/senolytics-prevent-atrial-arrhythmias-in-elderly-04-04-26/ Featured Articles Article 1: Impact of left atrial posterior wall isolation using pulsed-field ablation in patients undergoing repeat catheter ablation for atrial fibrillation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41519351 Summary: For patients undergoing repeat catheter ablation for atrial fibrillation (AF), a therapeutic approach involves either redo pulmonary vein isolation (PVI) alone or combining redo PVI with adjunctive posterior wall isolation (PWI). The use of pulsed-field ablation (PFA) is a significant consideration for achieving durable isolation in these procedures. This strategy directly addresses the clinical challenge of recurrent atrial fibrillation by targeting both pulmonary veins and the posterior wall. The comparison of these two ablation strategies provides insights into optimizing outcomes in repeat atrial fibrillation interventions. Article 2: Comparison of combined anatomic and functional modeling with purely anatomic assessment in scar-dependent ventricular tachycardia. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41513062 Summary: Identifying the critical substrate in scar-dependent ventricular tachycardia (VT) relies on precise mapping for ablation targets. Cardiac magnetic resonance imaging (M. R. I.) provides anatomic assessment (A. A.) to detect channels sustaining ventricular tachycardia. A refined approach involves heart digital twins, which integrate anatomic data with functional assessment for identifying the ventricular tachycardia isthmus. This combined anatomic and functional modeling offers a comprehensive method for characterizing the arrhythmogenic substrate compared to solely anatomic evaluations. Article 3: Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41513056 Summary: The study found that senolytic reduction of senescent cells effectively mitigated atrial arrhythmia vulnerability in aging rabbits. Cellular senescence contributes to age-related atrial fibrillation pathogenesis through its senescence-associated secretory phenotype, releasing proinflammatory and profibrotic factors. This research demonstrates a novel therapeutic strategy for age-related atrial arrhythmias by specifically targeting and reducing senescent cells. These findings indicate a direct link between cellular senescence and atrial fibrillation susceptibility in aging hearts. Article 4: Real-world performance of intrinsic antitachycardia pacing: Primary results from a global prospective postapproval registry study. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41500490 Summary: Intrinsic antitachycardia pacing (iATP) represents a closed-loop algorithm capable of automatically designing...

Welcome to Cardiology Today – Recorded April 04, 2026. This episode summarizes 5 key cardiology studies on topics like Acetazolamide and Implantable Loop Recorders. Key takeaway: Bradyarrhythmias Reveal Stroke’s Atrial Link. Article Links: Article 1: Interhospital Transfer for Heart Failure in the United States: A Patient and Hospital-level Analysis from GWTG-HF. (Journal of cardiac failure) Article 2: Cardiac rehabilitation after transcatheter aortic valve implantation before, during and after the COVID-19 pandemic: a whole-population study. (Heart (British Cardiac Society)) Article 3: Acetazolamide Effects on Natriuresis and Diuresis in Acute Heart Failure Treated with Furosemide and SGLT2i (SANDI). (ESC heart failure) Article 4: Paced QRS Morphology and Lead Location in Left Bundle Branch Area Pacing Assessed by Photon-Counting Cardiac Computed Tomography. (Heart rhythm) Article 5: Prevalence of clinically significant bradyarrhythmias in patients implanted with loop recorders for cryptogenic stroke: A manifestation of atrial cardiomyopathy? (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/bradyarrhythmias-reveal-strokes-atrial-link-04-04-26/ Featured Articles Article 1: Interhospital Transfer for Heart Failure in the United States: A Patient and Hospital-level Analysis from GWTG-HF. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41932644 Summary: This study characterized patients with Heart Failure who underwent interhospital transfer, establishing their demographic and clinical profiles. It found significant variations in the utilization of interhospital transfer among different hospitals across the United States. The data revealed distinctions in outcomes between transferred and non-transferred Heart Failure patients. This analysis provided foundational understanding of interhospital transfer patterns in this patient population. Article 2: Cardiac rehabilitation after transcatheter aortic valve implantation before, during and after the COVID-19 pandemic: a whole-population study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41932822 Summary: This whole-population study established patterns of cardiac rehabilitation participation following Transcatheter Aortic Valve Implantation across England. It found variations in participation rates before, during, and after the C. O. V. I. D. minus 19 pandemic. The research demonstrated a specific association between cardiac rehabilitation participation and the primary outcome of unplanned all-cause rehospitalization. This analysis provided critical evidence regarding cardiac rehabilitation’s impact on clinical outcomes in this patient group. Article 3: Acetazolamide Effects on Natriuresis and Diuresis in Acute Heart Failure Treated with Furosemide and SGLT2i (SANDI). Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41920937 Summary: The S. A. N. D. I. study investigated the natriuretic and diuretic effects of acetazolamide in patients with acute Heart Failure receiving intravenous furosemide and concomitant Sodium-Glucose Cotransporter-two Inhibitors. It found that acetazolamide provided significant natriuretic and diuretic benefits in this specific patient population, demonstrating enhanced decongestion. This research established the efficacy of adjunctive acetazolamide in acute Heart Failure patients who are also on Sodium-Glucose Cotransporter-two Inhibitors, addressing a previously unknown therapeutic gap. Article 4: Paced QRS Morphology and Lead Location in Left Bundle Branch Area Pacing Assessed by Photon-Counting Cardiac Computed Tomography. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41932670 Summary: This study elucidated the relationship between intra-septal lead position in Left Bundle Branch Area Pacing and paced QRS morphology. It found that ultra-high-resolution Photon-Counting Computed Tomography...

Welcome to Cardiology Today – Recorded April 03, 2026. This episode summarizes 5 key cardiology studies on topics like incident hypertension and quadruple guideline-directed medical therapies. Key takeaway: Glucagon-like Peptide-1 Agonists Cut Events Beyond Diabetes. Article Links: Article 1: Glucagon-like peptide-1 receptor agonists reduce experimental atherosclerosis progression, inflammatory biomarkers and cardiovascular events, irrespective of hyperglycaemia and obesity. (European heart journal) Article 2: Ten-minute asystolic warm ischemic time (AWIT) predicts mortality and severe primary graft dysfunction in donation after circulatory death hearts recovered with thoracoabdominal normothermic regional perfusion. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Time to Quadruple Therapy After Initial Diagnosis of Heart Failure With Reduced Ejection Fraction. (JAMA cardiology) Article 4: Blood Pressure Genetic Risk and Incident Hypertension at 2 to 7 Years Post Partum. (JAMA cardiology) Article 5: Effect of Sildenafil on Platelet Activation and Mediators of Vascular Remodeling During LVAD Support. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/glucagon-like-peptide-1-agonists-cut-events-beyond-diabetes-04-03-26/ Featured Articles Article 1: Glucagon-like peptide-1 receptor agonists reduce experimental atherosclerosis progression, inflammatory biomarkers and cardiovascular events, irrespective of hyperglycaemia and obesity. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41926331 Summary: Glucagon-like peptide-1 receptor agonists (G. L. P. minus 1 R. A.s) significantly reduced atherosclerosis burden and inflammatory biomarkers in experimental rabbit models. In clinical subjects, these agents decreased inflammatory biomarkers and major adverse cardiovascular events (MACE). These beneficial cardiovascular effects were observed irrespective of the patients’ glycemic status or obesity, indicating a direct cardiovascular protective mechanism. Article 2: Ten-minute asystolic warm ischemic time (AWIT) predicts mortality and severe primary graft dysfunction in donation after circulatory death hearts recovered with thoracoabdominal normothermic regional perfusion. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40701206 Summary: A ten-minute asystolic warm ischemic time (A. W. I. T.) during donation after circulatory death (D. C. D.) heart recovery significantly predicted increased mortality in adult heart transplant recipients. This prolonged warm ischemic time was also associated with severe primary graft dysfunction. These findings specifically apply to cardiac allografts recovered using thoracoabdominal normothermic regional perfusion (N. R. P.). Article 3: Time to Quadruple Therapy After Initial Diagnosis of Heart Failure With Reduced Ejection Fraction. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41920552 Summary: The study characterized the time to quadruple guideline-directed medical therapies (G. D. M. T.s) following an initial diagnosis of heart failure with reduced ejection fraction (H. F. rEF). It identified specific factors associated with achieving timely initiation of these therapies in a large cohort of patients. The findings provide contemporary estimates on the duration and facilitators of initiating optimal quadruple therapy for patients with H. F. rEF. Article 4: Blood Pressure Genetic Risk and Incident Hypertension at 2 to 7 Years Post Partum. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41920533 Summary: The study found that genetic risk for high systolic blood pressure (S. B. P.) significantly stratified the risk of new-onset hypertension in women. This...

Welcome to Cardiology Today – Recorded April 02, 2026. This episode summarizes 5 key cardiology studies on topics like atrial fibrillation ablation and immature neutrophils. Key takeaway: Hypothermic Preservation Boosts Heart Transplant Survival. Article Links: Article 1: Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription. (European heart journal) Article 2: Stroke and systemic embolism following atrial fibrillation ablation: the EMBOL-AF Global Registry. (European heart journal) Article 3: Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia-reperfusion. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Impact of HeartMate 3 left ventricular assist device infection on outcomes following heart transplant. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Improved 2-year heart transplant survival with moderate hypothermic donor heart preservation in the GUARDIAN heart registry. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/hypothermic-preservation-boosts-heart-transplant-survival-04-02-26/ Featured Articles Article 1: Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41920862 Summary: The Swedish Heart Failure Registry enabled a detailed assessment of patient adherence and persistence to quadruple pharmacotherapy for heart failure with reduced ejection fraction. This assessment confirmed the critical importance of patient adherence for the real-world uptake of these treatments. The study found specific associations between medication adherence and subsequent patient morbidity and mortality outcomes. Article 2: Stroke and systemic embolism following atrial fibrillation ablation: the EMBOL-AF Global Registry. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41914181 Summary: The E. M. B. O. L. minus A. F. Global Registry provided comprehensive data defining the incidence, outcomes, and procedural associations of stroke and systemic embolism following atrial fibrillation and left atrial flutter catheter ablation. This retrospective global registry captured detailed information from ablation centers worldwide, clarifying these previously poorly characterized complications. The registry’s findings illuminate critical insights into these post-ablation complications. Article 3: Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia-reperfusion. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41338428 Summary: This study found that immature neutrophils are elevated in human primary graft dysfunction. Researchers demonstrated a direct link between these immature neutrophils and granulocyte colony stimulating factor-driven injury in a murine model of lung ischemia-reperfusion. These findings indicate that immature neutrophils increase following lung transplantation and contribute to primary graft dysfunction severity. Article 4: Impact of HeartMate 3 left ventricular assist device infection on outcomes following heart transplant. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241030 Summary: This study found that infectious complications are...