Cardiology Today

Welcome to Cardiology Today – Recorded February 11, 2026. This episode summarizes 5 key cardiology studies on topics like qualitative research and heart failure. Key takeaway: AF Rate Control: Evidence Gap Identified. Article Links: Article 1: Changes in Haemodynamics, Cardiac Energetics, and Cell Signalling Pathways Induced by VA-ECMO with or without Left Ventricular Active Unloading. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Heart rate in early rhythm control therapy in patients with atrial fibrillation. (Heart (British Cardiac Society)) Article 3: From Representation to Reform: A Qualitative Study of Gender Equity in Interventional Cardiology. (The American journal of cardiology) Article 4: Comprehensive Assessment of Left Ventricular Function and Exercise Endurance in Patients with Hypertrophic Cardiomyopathy: The Combined Application of Left Ventricular Pressure-Strain Loop and Cardiopulmonary Exercise Testing. (Cardiology) Article 5: Peripheral Perfusion Index as a Marker of Hypoperfusion in Heart Failure. (Cardiology) Full episode page: https://podcast.explainheart.com/podcast/af-rate-control-evidence-gap-identified-02-11-26/ Featured Articles Article 1: Changes in Haemodynamics, Cardiac Energetics, and Cell Signalling Pathways Induced by VA-ECMO with or without Left Ventricular Active Unloading. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41667045 Summary: A.-E. C. M. O. with or without Left Ventricular Active Unloading. Veno-arterial extracorporeal membrane oxygenation (V. A.-E. C. M. O.), commonly used in refractory cardiogenic shock, is known to exacerbate left ventricular loading conditions and impair cardiac energetics. Adjunctive left ventricular unloading strategies are frequently combined with V. A.-E. C. M. O. to counteract these negative effects. These strategies, including intra-aortic balloon pump (I. A. B. P.) or Impella, aim to enhance myocardial recovery through activation of cardioprotective pathways. This approach directly addresses the recognized myocardial strain induced by V. A.-E. C. M. O. Article 2: Heart rate in early rhythm control therapy in patients with atrial fibrillation. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41663267 Summary: Current clinical recommendations advise preventing high heart rates in atrial fibrillation (A. F.) to reduce A. F.-related symptoms and morbidity. However, robust evidence demonstrating a strong relationship between lower heart rate during A. F. and a reduction in symptoms or cardiovascular complications is notably lacking. This analysis specifically compared patient symptoms, treatment strategies, and a composite endpoint of cardiovascular death, stroke, or hospitalization with worsening heart failure. It highlighted an ongoing clinical gap regarding optimal heart rate targets in early rhythm control therapy. Article 3: From Representation to Reform: A Qualitative Study of Gender Equity in Interventional Cardiology. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41666966 Summary: Women represent fewer than five percent of practicing interventional cardiologists in the United States. The W. E. C. A. R. E. study, through semi-structured interviews with 18 women interventional cardiology attendings and fellows, identified five major themes. These themes comprehensively characterize the unique career experiences, challenges, and support systems for women within the interventional cardiology subspecialty. This qualitative research provides specific insights into gender equity dynamics and potential areas for reform in the field. Article 4: Comprehensive Assessment of Left Ventricular Function and Exercise Endurance in Patients...

Welcome to Cardiology Today – Recorded February 11, 2026. This episode summarizes 5 key cardiology studies on topics like Blood pressure reduction and E. X. C. E. L. trial. Key takeaway: Macrophage circHIPK2 Directs Post-MI Fibrosis. Article Links: Article 1: Spontaneous Myocardial Infarction After Left Main Revascularization: The EXCEL Trial. (Circulation) Article 2: Computed tomography-guided vs conventional catheter ablation for ventricular tachycardia: the InEurHeart trial. (European heart journal) Article 3: Quadruple vs triple therapy for resistant hypertension: the QUADRO trial. (European heart journal) Article 4: Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction. (European heart journal) Article 5: Wine consumption, Mediterranean diet, and cardiovascular risk in two Spanish cohorts. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/macrophage-circhipk2-directs-post-mi-fibrosis-02-11-26/ Featured Articles Article 1: Spontaneous Myocardial Infarction After Left Main Revascularization: The EXCEL Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41664927 Summary: From the E. X. C. E. L. trial, this study established a systematic adjudication of spontaneous myocardial infarctions following left main coronary artery revascularization. It directly compared myocardial infarction events between patients receiving percutaneous coronary intervention and those undergoing coronary artery bypass graft surgery for left main coronary artery disease. The research determined the relative rates, etiology, and long-term prognostic implications of these spontaneous myocardial infarctions. This work provided definitive data on a critical adverse event after revascularization procedures. Article 2: Computed tomography-guided vs conventional catheter ablation for ventricular tachycardia: the InEurHeart trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41667137 Summary: The InEurHeart trial systematically compared computed tomography-guided ventricular tachycardia ablation with conventional ablation. This multicenter randomized controlled study involved 113 patients with prior myocardial infarction and clinically significant ventricular tachycardia. The trial established a direct comparison of the therapeutic effectiveness and safety profiles of these two ablation techniques. It provided foundational data for refining ablation strategies for complex ventricular tachycardia, especially in high-risk post-myocardial infarction patients. Article 3: Quadruple vs triple therapy for resistant hypertension: the QUADRO trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41667119 Summary: The Q. U. A. D. R. O. trial investigated the effectiveness of a quadruple single-pill combination versus triple antihypertensive therapy for resistant hypertension. This multicenter, phase three, randomized controlled study systematically compared blood pressure reduction outcomes between these two therapeutic approaches. The trial established the comparative efficacy of adding a fourth antihypertensive agent to triple therapy for patients with uncontrolled blood pressure. This provides crucial evidence for guiding treatment decisions in individuals with resistant hypertension to reduce cardiovascular morbidity and mortality. Article 4: Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41667113 Summary: This study identified circular R. N. A. circH. I. P. K. two as significantly upregulated in inflammatory cardiac macrophages after myocardial infarction. Researchers found that its expression directly correlated with post-myocardial infarction inflammation dynamics. The data demonstrated that circH. I. P. K. two functions as a key molecular switch for...

Welcome to Cardiology Today – Recorded February 10, 2026. This episode summarizes 5 key cardiology studies on topics like endothelium and cost-utility analysis. Key takeaway: AP-1 Genes Drive Lung Allograft Dysfunction. Article Links: Article 1: Incidence, Risk Factors, and Outcomes in Stressor-Associated Atrial Fibrillation: Insights From the VITAL-AF Trial. (Circulation) Article 2: Spatial transcriptomics reveals coordinated endothelial and epithelial activator protein-1 activation in CLAD. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Economic evaluation of ex-vivo lung perfusion for lung transplantation: a cost-utility analysis from a large Canadian centre. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Bone Benefits After Simultaneous Pancreas-kidney Transplantation Compared With the Pretransplant Period. (Transplantation) Article 5: Association between body mass index, plasma N-terminal pro-B-type natriuretic peptide, symptoms and outcome in patients referred for investigation of suspected heart failure. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/ap-1-genes-drive-lung-allograft-dysfunction-02-10-26/ Featured Articles Article 1: Incidence, Risk Factors, and Outcomes in Stressor-Associated Atrial Fibrillation: Insights From the VITAL-AF Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41662456 Summary: This study found that stressor-associated atrial fibrillation, defined as newly diagnosed atrial fibrillation in the presence of a reversible physiological stressor, is a common clinical entity. The VITAL-AF trial characterized this patient population, which comprised adults aged 65 years and older across primary care practices. This research highlights the widespread occurrence of this specific atrial fibrillation subtype, underscoring its clinical significance for diagnosis and management. The findings establish the importance of distinguishing stressor-associated atrial fibrillation for improved risk stratification in older adults. Article 2: Spatial transcriptomics reveals coordinated endothelial and epithelial activator protein-1 activation in CLAD. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41663041 Summary: Spatial transcriptomic analyses of human lungs with chronic lung allograft dysfunction revealed significant upregulation of activator protein-1 target genes, including JUNB and FOS. This upregulation was observed in both the epithelial and endothelial tissues of patients with chronic lung allograft dysfunction. The data demonstrated coordinated activator protein-1 activation in these cell types within affected lung allografts. This provides novel insight into the disease pathology of chronic lung allograft dysfunction. Article 3: Economic evaluation of ex-vivo lung perfusion for lung transplantation: a cost-utility analysis from a large Canadian centre. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41663040 Summary: Ex-vivo lung perfusion enables the evaluation and rehabilitation of potentially usable donor lungs outside the body prior to transplantation. This study established a comprehensive cost-utility analysis model for integrating ex-vivo lung perfusion into lung transplant programs, adopting a hospital perspective. The model utilizes individual-level simulation over a lifetime horizon for adults with end-stage lung disease awaiting transplantation. This research provides a critical tool for assessing the health economic implications of technologies that...

Welcome to Cardiology Today – Recorded February 09, 2026. This episode summarizes 5 key cardiology studies on topics like Accessory pathways and Omnipolar technology near-field. Key takeaway: CVP: Key to Heart Failure Chemoreceptor Sensitivity. Article Links: Article 1: A Novel Predictive Model for Left Atrial Low-Voltage Areas in Paroxysmal Atrial Fibrillation. (Heart rhythm) Article 2: Blood pressure and the risk of stroke in young patients with atrial fibrillation. (Heart rhythm) Article 3: High-Frequency Areas as an Electrophysiological Clue for Accessory Pathway Ablation: Characterizing Spatial Dissociation with Peak Frequency Mapping. (Heart rhythm) Article 4: Impact of linear ablation in persistent atrial fibrillation using a dual energy, wide-footprint catheter – Analysis from the SPHERE Per-AF Randomized Trial. (Heart rhythm) Article 5: Central venous pressure, rather than cardiac output, is associated with peripheral chemoreceptor sensitivity in heart failure patients with left ventricular assist device. (International journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/cvp-key-to-heart-failure-chemoreceptor-sensitivity-02-09-26/ Featured Articles Article 1: A Novel Predictive Model for Left Atrial Low-Voltage Areas in Paroxysmal Atrial Fibrillation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41655667 Summary: Left atrial low-voltage areas (LVAs) indicate atrial fibrosis and structural remodeling in a subset of paroxysmal atrial fibrillation patients. This study developed and validated a novel predictive model for identifying these LVAs in paroxysmal atrial fibrillation. Researchers enrolled patients receiving initial radiofrequency ablation. LVAs were specifically defined as regions with a bipolar voltage of less than 0.5. Article 2: Blood pressure and the risk of stroke in young patients with atrial fibrillation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41655666 Summary: Elevated blood pressure is associated with an increased stroke risk in atrial fibrillation patients. This study identified patients aged 20 to 39 years, newly diagnosed with atrial fibrillation, from the Korean Health Insurance Service database. The investigation focused on the effect of systolic blood pressure, diastolic blood pressure, and pulse pressure on ischemic stroke risk in this young atrial fibrillation cohort. This research addresses an important gap in understanding stroke risk factors for younger adults with atrial fibrillation. Article 3: High-Frequency Areas as an Electrophysiological Clue for Accessory Pathway Ablation: Characterizing Spatial Dissociation with Peak Frequency Mapping. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41655665 Summary: Catheter ablation is a curative therapy for atrioventricular reentrant tachycardia caused by accessory pathways, but precise localization is challenging. Omnipolar technology near-field (O. T. N. F.) provides a novel frequency-based analysis. This study characterized the spatial relationship between high-frequency areas identified by O. T. N. F. -derived peak frequency maps and successful accessory pathway ablation sites. This characterization helps improve precision in catheter ablation for atrioventricular reentrant tachycardia. Article 4: Impact of linear ablation in persistent atrial fibrillation using a dual energy, wide-footprint catheter – Analysis from the SPHERE Per-AF Randomized Trial. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41655663 Summary: Linear ablation lesions beyond pulmonary vein isolation in persistent atrial fibrillation often show variable efficacy. This study examined the performance of a novel dual-energy pulsed field/radiofrequency lattice-tip mapping and ablation system for linear ablation. The research also investigated the impact of this ablation strategy on outcomes within the SPHERE Persistent Atrial...

Welcome to Cardiology Today – Recorded February 08, 2026. This episode summarizes 5 key cardiology studies on topics like preeclampsia and maternal-fetal interface. Key takeaway: Adipose Tissue Drives Heart Failure Pathogenesis. Article Links: Article 1: Coronary Artery Compliance Modification after Non-Compliant Balloon Angioplasty and Intravascular Lithotripsy. (The American journal of cardiology) Article 2: Outcomes of High-Risk Pulmonary Embolism Stratified by Clinical Phenotype: Results from Two Specialized Pulmonary Embolism Centres. (The Canadian journal of cardiology) Article 3: Small extracellular vesicle-mediated adipocyte-cardiomyocyte crosstalk exacerbates heart failure with preserved ejection fraction. (Cardiovascular research) Article 4: SIRT1-NCOR2 Corepressor Modulates Trophoblast-Macrophage Interactions in Preeclampsia. (Hypertension (Dallas, Tex. : 1979)) Article 5: circMFN2 Regulates the IGF2BP3-PDK4 to Ameliorate Pulmonary Hypertension. (Hypertension (Dallas, Tex. : 1979)) Full episode page: https://podcast.explainheart.com/podcast/adipose-tissue-drives-heart-failure-pathogenesis-02-08-26/ Featured Articles Article 1: Coronary Artery Compliance Modification after Non-Compliant Balloon Angioplasty and Intravascular Lithotripsy. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41654158 Summary: Intravascular lithotripsy demonstrates efficacy in treating balloon-crossable calcified coronary lesions. It achieves this by inducing calcium fractures and improving coronary artery compliance. This study evaluates patients with calcified coronary artery lesions from the BENELUX-IVL prospective registry who received intravascular lithotripsy under intravascular ultrasound. The research provides a direct comparison of coronary artery compliance modification between intravascular lithotripsy and non-compliant balloon angioplasty. Article 2: Outcomes of High-Risk Pulmonary Embolism Stratified by Clinical Phenotype: Results from Two Specialized Pulmonary Embolism Centres. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41653976 Summary: High-risk pulmonary embolism presents with high early mortality and a heterogeneous patient population, ranging from cardiac arrest to obstructive shock or hypotension. Systemic thrombolysis remains the standard of care, but its use is limited by contraindications and bleeding risk. Catheter-directed therapies offer alternatives, though data on their use in high-risk pulmonary embolism is limited. This study characterized the clinical characteristics, management strategies, and outcomes across three distinct high-risk pulmonary embolism clinical phenotypes. Article 3: Small extracellular vesicle-mediated adipocyte-cardiomyocyte crosstalk exacerbates heart failure with preserved ejection fraction. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41645491 Summary: Heart failure with preserved ejection fraction (H. F. pEF) phenotypes were induced in male C57BL/6N mice using a high-fat diet combined with Nω-nitro-l-arginine methyl ester. The study found a causal relationship between adiposity and Heart Failure with Preserved Ejection Fraction pathogenesis. Resection of visceral adipose tissue blunted Heart Failure with Preserved Ejection Fraction phenotypes in mice, while transplantation of visceral adipose tissue exacerbated these phenotypes. Article 4: SIRT1-NCOR2 Corepressor Modulates Trophoblast-Macrophage Interactions in Preeclampsia. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41645896 Summary: Preeclampsia, a severe hypertensive disorder of pregnancy, is associated with low sirtuin 1 (SIRT1) levels in trophoblasts. Single-cell sequencing of systemic sirtuin 1 heterozygous knockout mice revealed abnormal activation of trophoblast retinoic acid receptor responder 2 (RARRES2) and macrophage chemokine-like...

Welcome to Cardiology Today – Recorded February 07, 2026. This episode summarizes 5 key cardiology studies on topics like cost-effectiveness and HeartMate 3. Key takeaway: Echo Phenotypes Boost PAH Risk Prediction. Article Links: Article 1: Pulsed Field Ablation vs Standard Radiofrequency Ablation for Typical Atrial Flutter: ADVANTAGE AF Trial Substudy. (Journal of the American College of Cardiology) Article 2: Pulmonary arterial hypertension: right ventricular phenotyping to improve risk assessment at follow-up. (European heart journal) Article 3: Heart Replacement Therapy in Young Patients: A Comparative Analysis of HeartMate 3 LVAD and Heart Transplant Using MOMENTUM 3 and UNOS Registry. (JACC. Heart failure) Article 4: Cost-Effectiveness of Semaglutide for Secondary Prevention of Cardiovascular Disease in US Adults. (JAMA cardiology) Article 5: Prognostic Implications of Mitral Regurgitation Across Hypertrophic Cardiomyopathy Subtypes: A Report From REVEAL-HCM Study. (Circulation. Heart failure) Full episode page: https://podcast.explainheart.com/podcast/echo-phenotypes-boost-pah-risk-prediction-02-07-26/ Featured Articles Article 1: Pulsed Field Ablation vs Standard Radiofrequency Ablation for Typical Atrial Flutter: ADVANTAGE AF Trial Substudy. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41653174 Summary: The ADVANTAGE AF trial substudy evaluated cavotricuspid isthmus ablation using either radiofrequency ablation or bipolar linear pulsed field ablation during persistent atrial fibrillation ablation. This study compared lesion characteristics, cavotricuspid isthmus ablation efficacy, and safety between these two ablation modalities. The comparison provided data on how each method performed when treating typical atrial flutter. Article 2: Pulmonary arterial hypertension: right ventricular phenotyping to improve risk assessment at follow-up. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41649944 Summary: This study found that echocardiography-derived phenotypes, describing various degrees of right ventricular remodelling and dysfunction, add prognostic information to current risk stratification tools for patients with pulmonary arterial hypertension. Data were prospectively collected from patients who underwent re-evaluation between six and 12 months after diagnosis across 11 centers of the Italian Pulmonary Hypertension Network. This demonstrates that these specific phenotypes provide enhanced prognostic insights for patient management. Article 3: Heart Replacement Therapy in Young Patients: A Comparative Analysis of HeartMate 3 LVAD and Heart Transplant Using MOMENTUM 3 and UNOS Registry. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41653179 Summary: V. A. D. and Heart Transplant Using MOMENTUM 3 and U. N. O. S. Registry. This study directly compared survival and adverse event rates between the HeartMate 3 left ventricular assist device and heart transplantation in young patients aged 18 to 49 years with advanced heart failure. The analysis integrated data from the MOMENTUM 3 trial and the United Network for Organ Sharing Registry. The findings provided a crucial head-to-head comparison of these two advanced heart failure therapies specifically for this younger age group. Article 4: Cost-Effectiveness of Semaglutide for Secondary Prevention of Cardiovascular Disease in US Adults. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41637062 Summary: S. Adults. This population-based cohort simulation study evaluated the cost-effectiveness and budget impact of semaglutide for secondary prevention of cardiovascular disease in U. S. adults. The study demonstrated that semaglutide reduces the risk of major adverse cardiovascular events in patients with overweight or obesity and cardiovascular disease but without diabetes. These findings provide critical information...

Welcome to Cardiology Today – Recorded February 07, 2026. This episode summarizes 5 key cardiology studies on topics like myocardial recovery and bicuspid aortic valve. Key takeaway: Insulin Resistance Impairs LVAD Recovery in Obese Heart Failure.. Article Links: Article 1: The Aldehyde Dehydrogenase 2 rs671 Variant Enhances Platelet Activation and Arterial Thrombosis. (Circulation) Article 2: Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve. (Circulation) Article 3: Natural History of Patients With Histologically Proven Acute Eosinophilic Myocarditis. (Circulation) Article 4: TRPM7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn2+ Homeostasis. (Circulation) Article 5: Insulin Resistance Compromises the Pentose Phosphate Pathway and Impairs Left Ventricular Assist Device-Mediated Myocardial Recovery in Obese Patients with Heart Failure. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/insulin-resistance-impairs-lvad-recovery-in-obese-heart-failure-02-07-26/ Featured Articles Article 1: The Aldehyde Dehydrogenase 2 rs671 Variant Enhances Platelet Activation and Arterial Thrombosis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41645907 Summary: The aldehyde dehydrogenase 2 (ALDH2) rs671 variant, prevalent in 30 percent to 50 percent of East Asians, was found to enhance platelet activation and arterial thrombosis. This specific polymorphism impairs ALDH2 function, directly contributing to its known association as a risk factor for acute myocardial infarction. The study demonstrated a clear link between the ALDH2 rs671 mutation and increased thrombotic risk, providing crucial mechanistic insights into acute myocardial infarction susceptibility in this population. Article 2: Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41645906 Summary: A genome-wide association study meta-analysis of 9631 bicuspid aortic valve cases among 65677 participants identified multiple new candidate genes and a significant polygenic contribution to bicuspid aortic valve etiology. Transcriptomic analyses, based on R. N. A. sequencing, further prioritized these genes, providing a deeper understanding of the genetic architecture of this frequent congenital heart defect. This comprehensive genetic and transcriptomic assessment clarified complex molecular mechanisms underlying bicuspid aortic valve development, expanding beyond previously limited gene associations. Article 3: Natural History of Patients With Histologically Proven Acute Eosinophilic Myocarditis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41645905 Summary: This international multicenter retrospective cohort study, encompassing 193 patients with histologically proven acute eosinophilic myocarditis from 53 centers, established the natural history of this condition. The study clarified specific clinical presentation patterns and identified associated systemic conditions, alongside current treatment approaches. It provided definitive data on the outcomes of acute eosinophilic myocarditis, offering a comprehensive overview of its progression and challenging previous perceptions of uniformly high mortality. Article 4: TRPM7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn2+ Homeostasis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41645903 Summary: Transient receptor potential melastatin 7 (TRPM7) deficiency protects against myocardial ischemia-reperfusion injury, a process contributing up to 50 percent of final infarct size in ischemic heart disease. The study found this protection is achieved by regulating intracellular zinc ion homeostasis....

Welcome to Cardiology Today – Recorded February 06, 2026. This episode summarizes 5 key cardiology studies on topics like heart transplantation and Cytomegalovirus. Key takeaway: Donor T. N. F. alpha Linked to Worse Kidney Grafts. Article Links: Article 1: Safety-Net Kidney Transplantation After Heart Transplantation: Early Real-World Outcomes Under the New Policy. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: A Molecular Reappraisal of Quilty Lesions: Insights from Tissue and Circulating Biomarkers in Heart Transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Circulating TNFα in deceased donors promotes kidney injury and associates with inferior short- and long-term graft function and survival. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 4: Frequency of Viral Monitoring to Detect Cytomegalovirus Infection and Prevent Disease in Solid Organ Transplant Recipients: An International, Multicenter Cohort Study. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 5: Abelacimab vs Rivaroxaban in Older Individuals With Atrial Fibrillation: A Prespecified Analysis of the Phase 2b AZALEA-TIMI 71 Trial. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/donor-t-n-f-alpha-linked-to-worse-kidney-grafts-02-06-26/ Featured Articles Article 1: Safety-Net Kidney Transplantation After Heart Transplantation: Early Real-World Outcomes Under the New Policy. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41643794 Summary: Among 4650 adult heart transplant recipients during the first 24 months of policy implementation, 987 patients, or 21.2 percent, met Safety-Net Kidney Transplantation eligibility within one year of heart transplantation. These eligible patients demonstrated significantly lower one-year survival compared with heart transplant recipients who did not meet eligibility criteria. The data highlights a substantial proportion of heart transplant recipients requiring subsequent kidney transplantation and indicates a clear association between this eligibility and adverse survival outcomes. Article 2: A Molecular Reappraisal of Quilty Lesions: Insights from Tissue and Circulating Biomarkers in Heart Transplantation. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41643793 Summary: Quilty lesions are characterized by nodular T-lymphocyte infiltrates found in the endocardium of transplanted hearts. The clinical significance of these lesions remains controversial, with their precise relationship to rejection not fully understood in clinical practice. This study utilized tissue-based transcriptomic diagnostics, specifically Molecular Microscope Analysis, to investigate the link between Quilty lesions and cardiac rejection. Understanding the impact of Quilty lesions on clinical outcomes for heart transplant recipients represents a critical area of ongoing research. Article 3: Circulating TNFα in deceased donors promotes kidney injury and associates with inferior short- and long-term graft function and survival. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41644055 Summary: N. F. alpha in deceased donors promotes kidney injury and associates with inferior short- and long-term...

Welcome to Cardiology Today – Recorded February 05, 2026. This episode summarizes 5 key cardiology studies on topics like risk prediction and heart failure. Key takeaway: Early TAVR Superior for Asymptomatic Aortic Stenosis. Article Links: Article 1: PREVENT Equations in Young Adults: Fairness, Calibration, and Performance Across Racial and Ethnic Groups. (Journal of the American College of Cardiology) Article 2: 1-Year Outcomes of Novel Balloon-Expandable vs Contemporary Transcatheter Heart Valves in Severe Aortic Stenosis: The LANDMARK Trial. (Journal of the American College of Cardiology) Article 3: Left Ventricular Health and TAVR Timing in Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial. (Journal of the American College of Cardiology) Article 4: Heart failure in the Portuguese population aged ≥50 years: prevalence and phenotypes in the PORTHOS study. (European heart journal) Article 5: Subvalvular aortic stenosis in adults: clinical course and long-term outcomes. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/early-tavr-superior-for-asymptomatic-aortic-stenosis-02-05-26/ Featured Articles Article 1: PREVENT Equations in Young Adults: Fairness, Calibration, and Performance Across Racial and Ethnic Groups. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41636665 Summary: Cardiovascular disease is increasing among young adults, highlighting a critical need for effective primary prevention strategies. The American Heart Association’s PREVENT (Predicting Risk of Cardiovascular Disease Events) equations estimate risk for cardiovascular disease, atherosclerotic cardiovascular disease, and heart failure. This analysis provided insights into the performance and algorithmic fairness of these base and Social Deprivation Index-augmented PREVENT equations across various racial and ethnic groups. The study emphasized the importance of equitable and accurately calibrated risk prediction tools for diverse young adult populations. Article 2: 1-Year Outcomes of Novel Balloon-Expandable vs Contemporary Transcatheter Heart Valves in Severe Aortic Stenosis: The LANDMARK Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41384893 Summary: The LANDMARK trial found that the Myval balloon-expandable Transcatheter Heart Valve (T. H. V.) series was noninferior to the most commonly used contemporary SAPIEN and Evolut Series T. H. V.s for the 30-day early safety endpoint. This finding was observed in participants with symptomatic severe native aortic stenosis. The study thereby established the initial safety profile of the novel Myval valve in comparison to established devices. Further evaluation of its one year clinical outcomes, hemodynamic performances, and quality of life is ongoing. Article 3: Left Ventricular Health and TAVR Timing in Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41128701 Summary: The EARLY TAVR trial definitively demonstrated that early Transcatheter Aortic Valve Replacement (TAVR) was superior to clinical surveillance for patients with asymptomatic severe aortic stenosis. This finding revealed a clear benefit of early intervention in improving patient outcomes. The subsequent analysis examined how baseline Left Ventricular (L. V.) health impacted this treatment effect and observed longitudinal L. V. health under different treatment strategies. These observations underscore the critical role of L. V. function in optimizing management decisions for asymptomatic severe aortic stenosis. Article 4: Heart failure in the Portuguese population aged ≥50 years: prevalence and phenotypes in the PORTHOS study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41641552 Summary: Heart failure...

Welcome to Cardiology Today – Recorded February 04, 2026. This episode summarizes 5 key cardiology studies on topics like high-intensity interval training and acute exercise. Key takeaway: C. T. Predicts Stroke Clot Removal Success. Article Links: Article 1: General Anesthesia Versus Conscious Sedation for Mechanical Thrombectomy in Patients With Acute Ischemic Stroke in the MOST Trial. (Journal of the American Heart Association) Article 2: Computed Tomography Radiomic Signatures Associated With Neutrophil Extracellular Trap Enrichment and First-Pass Outcome in Ischemic Stroke Thrombi. (Journal of the American Heart Association) Article 3: Exploring Sex Differences in Stroke Outcomes: A Comprehensive Analysis From the SPAN 1 Trial. (Journal of the American Heart Association) Article 4: Increased Incidence of De Novo Malignancies Compared With Malignancy Recurrences in Survivors of Cancer Undergoing Heart Transplantation. (Journal of the American Heart Association) Article 5: Effects of Acute Exercise and 12-Week High-Intensity Interval Training on Inflammatory Biomarkers in Stable Coronary Artery Disease: A Randomized Controlled Trial. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/c-t-predicts-stroke-clot-removal-success-02-04-26/ Featured Articles Article 1: General Anesthesia Versus Conscious Sedation for Mechanical Thrombectomy in Patients With Acute Ischemic Stroke in the MOST Trial. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41631770 Summary: The abstract reports that several observational studies supported conscious sedation for endovascular thrombectomy in acute ischemic stroke and associated general anesthesia with poor functional outcomes. Conversely, recent randomized controlled trials have shown no difference in functional outcomes between general anesthesia and conscious sedation. This highlights a critical ongoing debate regarding the optimal anesthesia choice for mechanical thrombectomy in patients with acute ischemic stroke. The abstract’s context emphasizes the importance of understanding the definitive impact of anesthesia type on patient functional recovery. Article 2: Computed Tomography Radiomic Signatures Associated With Neutrophil Extracellular Trap Enrichment and First-Pass Outcome in Ischemic Stroke Thrombi. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41631768 Summary: This study integrated paired radiomics and transcriptomics from 32 ischemic stroke clots retrieved by mechanical thrombectomy. The analysis identified neutrophil extracellular trap enrichment within these clots as a predictor of first-pass mechanical thrombectomy success. Results demonstrated the potential for noninvasively detecting neutrophil extracellular trap enrichment using prethrombectomy computed tomography imaging. This represents a significant advancement for predicting successful clot removal and refining treatment approaches in acute ischemic stroke. Article 3: Exploring Sex Differences in Stroke Outcomes: A Comprehensive Analysis From the SPAN 1 Trial. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41631765 Summary: The abstract establishes that stroke is a sexually dimorphic disease, demonstrating differences in risk factors, incidence, outcomes, and treatment responses between men and women. It highlights that previous preclinical studies supporting these sex differences often originated from single-site studies with small sample sizes. Therefore, validating these variations across diverse research settings, as intended by the S. P. A. N. (Stroke Preclinical Assessment Network) trial, holds significant clinical importance. Understanding these inherent sex-based differences is crucial for developing more targeted and effective stroke management strategies. Article 4: Increased Incidence of De...

Welcome to Cardiology Today – Recorded February 03, 2026. This episode summarizes 5 key cardiology studies on topics like cardiac implantable electronic devices and quality of life. Key takeaway: New Extravascular Defibrillator Offers Pacing. Article Links: Article 1: Defining an Optimal Result of Transcatheter Tricuspid Valve Intervention: Results From the Tri-QOL Study. (Circulation) Article 2: Hidden Structure of Care Coordination in Heart Failure Care Transitions: A Mixed-method Network Analysis of Clinical Notes. (Journal of cardiac failure) Article 3: Acute results of the ASCEND EV study: A new modality of parasternal extravascular implantable cardioverter-defibrillator therapy including antitachycardia pacing. (Heart rhythm) Article 4: Cardiac magnetic resonance to evaluate 3-dimensional ventricular substrate depth: Prognostic implications for ventricular tachycardia ablation approach. (Heart rhythm) Article 5: Drug-coated balloon venoplasty for symptomatic lead-related venous stenosis. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/new-extravascular-defibrillator-offers-pacing-02-03-26/ Featured Articles Article 1: Defining an Optimal Result of Transcatheter Tricuspid Valve Intervention: Results From the Tri-QOL Study. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41628259 Summary: Recent randomized trials demonstrated that transcatheter tricuspid valve interventions improve symptoms, function, and quality of life for patients with severe tricuspid regurgitation. These trials showed that the extent of health status improvement correlates directly with the degree of tricuspid regurgitation reduction. This finding establishes a crucial link between procedural success and patient-reported outcomes for this patient population. Article 2: Hidden Structure of Care Coordination in Heart Failure Care Transitions: A Mixed-method Network Analysis of Clinical Notes. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41628682 Summary: Patients with heart failure, particularly those of lower socioeconomic position, exhibit vulnerability to adverse outcomes resulting from care fragmentation. Care coordination effectively mitigates this care fragmentation, improving patient safety and efficacy. This highlights the critical importance of comprehensive clinician networks to enhance patient outcomes during heart failure care transitions. Article 3: Acute results of the ASCEND EV study: A new modality of parasternal extravascular implantable cardioverter-defibrillator therapy including antitachycardia pacing. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41248780 Summary: The AtaCor parasternal extravascular implantable cardioverter-defibrillator system provides defibrillation and antitachycardia pacing therapy from outside the heart. This new modality utilizes an extravascular lead positioned along the left parasternum, designed to overcome limitations of existing implantable cardioverter-defibrillators. The ASCEND E. V. study introduced this novel system for patients with class one or two A indications for implantable cardioverter-defibrillators, focusing on demonstrating the system’s implant success, acute performance, and 30-day safety. Article 4: Cardiac magnetic resonance to evaluate 3-dimensional ventricular substrate depth: Prognostic implications for ventricular tachycardia ablation approach. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41205889 Summary: Substrate-based catheter ablation demonstrates effectiveness for scar-related ventricular tachycardia. Cardiac magnetic resonance is a valuable tool for assessing the arrhythmic substrate, thereby guiding ablation strategies. The study found that understanding three-dimensional ventricular substrate depth via cardiac magnetic resonance has prognostic implications for selecting the optimal ventricular tachycardia ablation approach. This...

Welcome to Cardiology Today – Recorded February 02, 2026. This episode summarizes 5 key cardiology studies on topics like stroke risk and cardiac lymphatics. Key takeaway: Lymphatics Predict Heart Transplant Survival.. Article Links: Article 1: Prognostic Value of Artificial Intelligence-Enabled Electrocardiography-Derived Diastolic Dysfunction Grading and Trajectory in Patients Undergoing Transcatheter Aortic Valve Replacement. (Journal of the American Heart Association) Article 2: Association Between Living Environmental Factors and Stroke in Middle-Aged and Older Chinese Adults: A Nationwide Prospective Cohort Study. (Journal of the American Heart Association) Article 3: High Prevalence of Cerebrovascular Calcifications and Clinical Correlates in Indigenous Bolivian Forager-Horticulturalists: A Population-Based Observational Study. (Journal of the American Heart Association) Article 4: Patient-Specific Computational Flow Simulation Reveals Adverse Hemodynamic Factors Associated With Occlusion of Directional Branches After Fenestrated-Branched Endovascular Aneurysm Repair. (Journal of the American Heart Association) Article 5: Cardiac Lymphatics Predict Survival After Heart Transplantation. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/lymphatics-predict-heart-transplant-survival-02-02-26/ Featured Articles Article 1: Prognostic Value of Artificial Intelligence-Enabled Electrocardiography-Derived Diastolic Dysfunction Grading and Trajectory in Patients Undergoing Transcatheter Aortic Valve Replacement. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41614319 Summary: This study found that artificial intelligence-enabled electrocardiography can classify diastolic dysfunction grades in patients undergoing transcatheter aortic valve replacement for severe aortic stenosis. Researchers applied a validated artificial intelligence model to 3197 baseline 12-lead electrocardiograms from these patients. This application provides a novel method for identifying cardiac dysfunction in this high-risk population, laying the groundwork for future prognostic assessments. Article 2: Association Between Living Environmental Factors and Stroke in Middle-Aged and Older Chinese Adults: A Nationwide Prospective Cohort Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41614318 Summary: This nationwide prospective cohort study demonstrated an association between a comprehensive set of living environmental factors and stroke in middle-aged and older Chinese adults. Researchers analyzed data from the China Health and Retirement Longitudinal Study, considering ambient fine particulate matter, indoor fuel use, tap water use, room temperature, and residence type. This research established the relevance of specific environmental exposures to stroke risk in a large population, highlighting multifaceted influences beyond traditional risk factors. Article 3: High Prevalence of Cerebrovascular Calcifications and Clinical Correlates in Indigenous Bolivian Forager-Horticulturalists: A Population-Based Observational Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41614317 Summary: This population-based observational study found a high prevalence of cerebrovascular calcifications among indigenous Bolivian forager-horticulturalists. The study also identified specific clinical correlates for these calcifications within this unique population. These findings challenge assumptions derived solely from industrialized populations regarding intracranial arteriosclerosis and its risk factors in diverse lifestyles. Article 4: Patient-Specific Computational Flow Simulation Reveals Adverse Hemodynamic Factors Associated With Occlusion of Directional Branches After Fenestrated-Branched Endovascular Aneurysm Repair. Journal: Journal of the...

Welcome to Cardiology Today – Recorded February 01, 2026. This episode summarizes 5 key cardiology studies on topics like warm ischemic time and chronic antibody-mediated rejection. Key takeaway: Chlorthalidone vs Hydrochlorothiazide: No C. V. Risk Difference. Article Links: Article 1: Barriers and opportunities in donation after circulatory death heart transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Enhanced Diagnosis of Chronic Antibody-mediated Rejection Using Peritubular Capillary Multilayering. (Transplantation) Article 3: Comparative Effectiveness and Outcomes of Nebivolol Versus Other Beta Blockers in Patients With Hypertension: A Multicenter Cohort Study. (Journal of the American Heart Association) Article 4: Pacemaker Implantation Rates With the Self-Expandable Navitor Valve. (Journal of the American Heart Association) Article 5: Per-Protocol Analysis of Chlorthalidone Versus Hydrochlorothiazide for Cardiovascular Event Prevention-Diuretic Comparison Project. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/chlorthalidone-vs-hydrochlorothiazide-no-c-v-risk-difference-02-01-26/ Featured Articles Article 1: Barriers and opportunities in donation after circulatory death heart transplantation. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40480320 Summary: Heart utilization from donation after circulatory death (DCD) donors remains highly variable across the United States, which results in missed transplantation opportunities. This national registry analysis investigated donor characteristics, including age and warm ischemic time, in donation after circulatory death cases. The study identified these factors as relevant in the assessment of potential heart donors. Findings suggest better understanding of these variables could improve organ utilization rates. Article 2: Enhanced Diagnosis of Chronic Antibody-mediated Rejection Using Peritubular Capillary Multilayering. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41063352 Summary: This study found peritubular capillary multilayering (PTCML) is an ultrastructural feature of chronic antibody-mediated rejection (AMR) in 2541 kidney samples. Epidemiological modeling demonstrated that younger recipients, living donation, early chronic antibody-mediated rejection, and pulse corticosteroid rejection treatment were associated factors. Later presentation and higher donor-specific antibodies also showed an association with chronic antibody-mediated rejection. The data thus clarifies diagnostic relationships for this condition. Article 3: Comparative Effectiveness and Outcomes of Nebivolol Versus Other Beta Blockers in Patients With Hypertension: A Multicenter Cohort Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41614331 Summary: This multicenter cohort study compared the real-world effectiveness of nebivolol, a third-generation beta blocker, against other beta blockers for hypertension management. The study determined nebivolol’s impact on blood pressure and heart rate control. It also clarified associated clinical outcomes in patients with hypertension. The data contributes to understanding optimal beta blocker selection in clinical practice. Article 4: Pacemaker Implantation Rates With the Self-Expandable Navitor Valve. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41614325 Summary: This study compared 30-day permanent pacemaker implantation (PPI) rates between transcatheter aortic valve replacement (TAVR) patients receiving the self-expandable Navitor system and those receiving the Evolut system. The comparison involved 148 Navitor...

Welcome to Cardiology Today – Recorded February 01, 2026. This episode summarizes 5 key cardiology studies on topics like cardiac protection and delayed kidney graft function. Key takeaway: Dual Organ Perfusion: Superior Cardiac Safety. Article Links: Article 1: Add-on therapy with parenteral prostacyclin analogues in patients with pulmonary arterial hypertension: Insights from the COMPERA registry. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Superior cardiac protection in combined ex-situ perfusion of heart and liver. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Method for generating right ventricular pressure-volume loops in routine practice. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Outcomes with Impella CP in acute myocardial infarction vs heart failure cardiogenic shock: Insights from the Cardiogenic Shock Working Group. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Impact of delayed kidney graft function on long-term outcomes in simultaneous heart-kidney transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/dual-organ-perfusion-superior-cardiac-safety-02-01-26/ Featured Articles Article 1: Add-on therapy with parenteral prostacyclin analogues in patients with pulmonary arterial hypertension: Insights from the COMPERA registry. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41201625 Summary: This study identified 495 pretreated patients with pulmonary arterial hypertension who received add-on parenteral prostacyclin analogue therapy from the COMPERA registry. The cohort included patients with idiopathic, heritable, drug-associated pulmonary arterial hypertension, connective tissue disease-associated pulmonary arterial hypertension, or congenital heart disease-associated pulmonary arterial hypertension. All patients were pretreated with at least one pulmonary arterial hypertension specific therapy before receiving the add-on treatment. This investigation provides a real-world characterization of patients receiving this advanced combination therapy for pulmonary arterial hypertension. Article 2: Superior cardiac protection in combined ex-situ perfusion of heart and liver. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41005516 Summary: This study demonstrated superior cardiac protection when using combined ex-situ heart-liver perfusion compared to isolated ex-situ heart perfusion in porcine hearts. It built upon previous findings that experimental ex-situ organ perfusion with cross-circulation significantly extends safe preservation times. The study also perfused discarded human donor hearts ex-situ, providing data on this advanced preservation technique. This approach improved cardiac preservation beyond what isolated heart perfusion achieved. Article 3: Method for generating right ventricular pressure-volume loops in routine practice. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40947078 Summary: This study successfully validated a novel method for reconstructing right ventricular pressure-volume loops directly from pressure waveforms. These waveforms were acquired during...

Welcome to Cardiology Today – Recorded January 31, 2026. This episode summarizes 5 key cardiology studies on topics like cardiovascular-kidney-metabolic syndrome and sinoatrial node dysfunction. Key takeaway: Fontan Liver Biomarkers Predict Survival. Article Links: Article 1: Cardiovascular-Kidney-Metabolic Medication Eligibility Across National Survey, Community-Based, and Ambulatory Healthcare Samples. (JAMA cardiology) Article 2: Non-invasive biomarkers of liver disease as prognostic indicators in patients with Fontan circulation. (Heart (British Cardiac Society)) Article 3: Sex differences in the prevalence and risk factors for aortic valve calcification in the general population. (Heart (British Cardiac Society)) Article 4: Comprehensive risk factor analysis of sick sinus syndrome: a genetic, sociodemographic, clinical and laboratory investigation using the UK Biobank data. (Heart (British Cardiac Society)) Article 5: Finerenone, Liver Biomarkers, and Heart Failure With Mildly Reduced/Preserved Ejection Fraction: An Analysis of FINEARTS-HF. (Circulation. Heart failure) Full episode page: https://podcast.explainheart.com/podcast/fontan-liver-biomarkers-predict-survival-01-31-26/ Featured Articles Article 1: Cardiovascular-Kidney-Metabolic Medication Eligibility Across National Survey, Community-Based, and Ambulatory Healthcare Samples. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41604173 Summary: The prevalence of obesity and cardiovascular-kidney-metabolic syndrome is demonstrably increasing. This rise, coupled with expanding indications for glucagonlike peptide one receptor agonists, sodium-glucose cotransporter-two inhibitors, and nonsteroidal mineralocorticoid antagonists, underscores a significant clinical challenge. It confirms a crucial need to quantify the proportion of adults who meet eligibility criteria for these therapies, including for combination treatments. This information is critical for understanding current treatment gaps and optimizing patient care in an evolving landscape. Article 2: Non-invasive biomarkers of liver disease as prognostic indicators in patients with Fontan circulation. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41617484 Summary: The Fontan procedure carries a burden of long-term cardiac and non-cardiac complications and contributes to early mortality. Non-invasive liver fibrosis biomarkers, specifically FibroSURE testing, represent a potential prognostic tool for these patients. This study demonstrated the utility of such biomarkers to predict transplant-free survival in adults with Fontan circulation. This offers a valuable non-invasive strategy for risk stratification and management guidance in this complex patient population. Article 3: Sex differences in the prevalence and risk factors for aortic valve calcification in the general population. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41611525 Summary: Aortic valve calcification is a recognized precursor to aortic stenosis, influenced by inflammation and lipid infiltration. This study utilized data from 30154 individuals aged 50 to 64 years from the general population to investigate sex-specific differences in aortic valve calcification. It provides characterization of the prevalence and risk factors for aortic valve calcification, particularly highlighting sex-specific variations. Understanding these differences is crucial for targeted prevention and earlier intervention strategies in the general population. Article 4: Comprehensive risk factor analysis of sick sinus syndrome: a genetic, sociodemographic, clinical and laboratory investigation using the UK Biobank data. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41605626 Summary: K. Biobank data. Sick sinus syndrome and atrial fibrillation frequently co-exist, often initiating or perpetuating each other....

Welcome to Cardiology Today – Recorded January 31, 2026. This episode summarizes 5 key cardiology studies on topics like heart failure endpoints and long-term outcomes. Key takeaway: Frozen Elephant Trunk: 20-Year Aortic Dissection Outcomes. Article Links: Article 1: DAPK2 Regulates PKM2 Phosphorylation at Threonine 45 to Facilitate Disturbed Flow-Induced Atherosclerosis. (Circulation) Article 2: Heart failure with preserved ejection fraction in adults with congenital heart disease. (European heart journal) Article 3: Frozen elephant trunk for acute type A aortic dissection: long-term outcomes over two decades. (European heart journal) Article 4: Heart Failure Endpoints in FDA Pivotal Trials. (European heart journal) Article 5: Invasive mold infection in heart transplant recipients: a nationwide multicenter matched case-control study between 2008 and 2022 in France. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Full episode page: https://podcast.explainheart.com/podcast/frozen-elephant-trunk-20-year-aortic-dissection-outcomes-01-31-26/ Featured Articles Article 1: DAPK2 Regulates PKM2 Phosphorylation at Threonine 45 to Facilitate Disturbed Flow-Induced Atherosclerosis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41614276 Summary: This study found that death-associated protein kinase 2 regulates pyruvate kinase M2 phosphorylation at threonine 45. This regulation facilitates disturbed flow-induced atherosclerosis, a process initiated by oscillatory shear stress. The data clarify a crucial molecular mechanism by which oscillatory shear stress leads to endothelial cell activation and atherosclerotic plaque formation. This provides novel understanding of the precise pathways contributing to vascular disease. Article 2: Heart failure with preserved ejection fraction in adults with congenital heart disease. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41614664 Summary: This retrospective multicenter cohort study determined the prevalence, characteristics, and hospitalization burden of Heart Failure with Preserved Ejection Fraction among adults with congenital heart disease. The study included 4507 adults with congenital heart disease who had biventricular heart physiology and a systemic left ventricle. Results offered detailed insights into the clinical profile of this patient population and the specific impact of Heart Failure with Preserved Ejection Fraction on hospitalizations. This clarifies the extent and nature of Heart Failure with Preserved Ejection Fraction within this complex patient group. Article 3: Frozen elephant trunk for acute type A aortic dissection: long-term outcomes over two decades. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41614598 Summary: This study evaluated the early and long-term outcomes of the frozen elephant trunk and total arch replacement technique in 850 patients with acute type A aortic dissection. The patient cohort, treated between April 2003 and December 2014, had a mean age of 46.5 years; 19.9 percent were women, and 136 patients presented with malperfusion syndrome. The findings provided definitive data on the efficacy and durability of this aggressive surgical approach for acute type A aortic dissection over two decades. This demonstrates the long-term clinical profile and safety of extended arch repair in this complex patient population. Article 4: Heart Failure Endpoints in FDA Pivotal Trials. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41614592 Summary: D. A. Pivotal Trials. This analysis found that traditional heart failure medication approval, based on reducing cardiovascular death or heart failure hospitalization, is evolving. Expanding use of effective medicines has successfully reduced hospitalization and mortality rates, making incremental...

Welcome to Cardiology Today – Recorded January 30, 2026. This episode summarizes 5 key cardiology studies on topics like peri-operative myocardial infarction and cardiac complications. Key takeaway: Mitochondrial Transfer Cuts Cardiac Reperfusion Injury. Article Links: Article 1: Peri-operative myocardial infarction/injury after non-cardiac surgery: association between cardiologist evaluation and outcomes. (European heart journal) Article 2: Long-term exposure to wildfire smoke particulate matter and incident stroke: a US nationwide study. (European heart journal) Article 3: Pushing the Limits of Death-Rapid Ultra-Oxygenated Recovery Without Pre-Implant Heart Reanimation in Circulatory Death With Prolonged ‘No-Touch’ Period. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Circulating Mitochondrial Transfer Carrying Dihydroorotate Dehydrogenase Reduces Oxidative Cell Death in Prolonged Cold-induced Cardiac Reperfusion Injury in Heart Transplantation. (Transplantation) Article 5: One-Year Outcomes in Patients Hospitalized for Heart Failure With Reduced Ejection Fraction Prescribed Quadruple Medical Therapy at Discharge. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/mitochondrial-transfer-cuts-cardiac-reperfusion-injury-01-30-26/ Featured Articles Article 1: Peri-operative myocardial infarction/injury after non-cardiac surgery: association between cardiologist evaluation and outcomes. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41610880 Summary: Peri-operative myocardial infarction or injury is a common cardiac complication observed after non-cardiac surgery. In a multicenter prospective study, cardiologist evaluation of patients developing peri-operative myocardial infarction or injury was inconsistently applied within active surveillance programs. This inconsistent evaluation was primarily due to staffing constraints. The study highlighted a significant variability in specialist involvement for this high-risk patient population. Article 2: Long-term exposure to wildfire smoke particulate matter and incident stroke: a US nationwide study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41587749 Summary: Long-term exposure to wildfire smoke fine particulate matter, specifically P. M. two point five, constitutes a growing public health concern. While short-term exposure is established to impact cardiovascular outcomes, the long-term effects on incident stroke remained significantly understudied. Data from Medicare beneficiaries aged sixty-five years and older from 2007 to 2018 were analyzed to investigate the association between prolonged wildfire smoke exposure and stroke incidence. This research established the critical need for further understanding this environmental risk factor’s impact on cerebrovascular health. Article 3: Pushing the Limits of Death-Rapid Ultra-Oxygenated Recovery Without Pre-Implant Heart Reanimation in Circulatory Death With Prolonged ‘No-Touch’ Period. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41611105 Summary: Researchers developed a novel method for rapid ultra-oxygenated recovery of cardiac allografts from donation after circulatory death donors. This technique enables successful heart transplantation without the need for traditional pre-implant heart reanimation, a process historically used to ensure graft viability and function. This innovative approach expands the donor pool for adult heart transplantation by optimizing graft retrieval. Clinical application considerations persist regarding its global use, particularly in scenarios involving prolonged ‘no-touch’ periods. Article 4: Circulating Mitochondrial Transfer Carrying Dihydroorotate Dehydrogenase...

Welcome to Cardiology Today – Recorded January 29, 2026. This episode summarizes 5 key cardiology studies on topics like glycated haemoglobin and drug-eluting stents. Key takeaway: Breast Cancer Unmasks Latent P. A. H. Susceptibility. Article Links: Article 1: Drug-Coated Balloon Angioplasty vs Up-Front Stenting for De Novo CAD: 3-Year Follow-Up of REC-CAGEFREE I Trial. (Journal of the American College of Cardiology) Article 2: Wearable-Derived Training Load and Coronary Atherosclerosis in Middle-Aged and Older Athletes and Physically Active Controls: A New Perspective From the Master@Heart Study. (Circulation) Article 3: Breast Cancer Reveals Latent BMPR2-Related Susceptibility to Pulmonary Hypertension. (Circulation) Article 4: GLP-1R agonists and heart failure: novel beneficial effects suggested by Mendelian randomization. (European heart journal) Article 5: T cells in acute and chronic myocarditis: from diagnosis to treatment. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/breast-cancer-unmasks-latent-p-a-h-susceptibility-01-29-26/ Featured Articles Article 1: Drug-Coated Balloon Angioplasty vs Up-Front Stenting for De Novo CAD: 3-Year Follow-Up of REC-CAGEFREE I Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41194754 Summary: The REC-CAGEFREE I trial found that drug-coated balloon angioplasty with rescue stenting did not achieve noninferiority compared to intended drug-eluting stent implantation for treating de novo lesions in coronary artery disease. This concrete outcome was observed at the two-year follow-up. The data therefore demonstrated that the drug-coated balloon strategy was not equivalent to drug-eluting stents for these patients. Article 2: Wearable-Derived Training Load and Coronary Atherosclerosis in Middle-Aged and Older Athletes and Physically Active Controls: A New Perspective From the Master@Heart Study. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41608826 Summary: The Master@Heart study confirmed that middle-aged and older endurance athletes exhibit an increased prevalence of coronary artery disease on coronary computed tomography angiography compared to healthy controls, despite having similarly low cardiovascular risk profiles. This observational cross-sectional analysis then utilized objective wearable-derived training load data to investigate its impact on coronary artery disease risk. The study’s novel approach addressed the previously unknown impact of objective training load measurements on cardiovascular outcomes in this athletic population. This represents a key advancement in quantifying training exposure more accurately than traditional self-reported data. Article 3: Breast Cancer Reveals Latent BMPR2-Related Susceptibility to Pulmonary Hypertension. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41603037 Summary: M. P. R. 2-Related Susceptibility to Pulmonary Hypertension. This study revealed that breast cancer unmasks a latent susceptibility to pulmonary arterial hypertension associated with bone morphogenetic protein receptor type two (B. M. P. R. 2) mutations. Researchers found that these B. M. P. R. 2 mutations, known to cause heritable pulmonary arterial hypertension, also play a role in tumor-suppressive functions. The findings link these two diseases, disproportionately affecting women, through the genetic role of B. M. P. R. 2 alterations. This provides novel insights into the complex interplay between genetic predispositions and cancer development influencing cardiovascular health. Article 4: GLP-1R agonists and heart failure: novel beneficial effects suggested by Mendelian randomization. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41609518 Summary: L. P. minus 1 R agonists and heart failure: novel beneficial effects suggested by Mendelian randomization. This study utilized two-sample...

Welcome to Cardiology Today – Recorded January 29, 2026. This episode summarizes 5 key cardiology studies on topics like P2Y12 inhibitor monotherapy and public reporting. Key takeaway: Tailoring Antiplatelets After P. C. I. for A. C. S.. Article Links: Article 1: Public Reporting and Case Selection in Congenital Heart Surgery: Signals From a Multicenter Observational Study. (Journal of the American College of Cardiology) Article 2: Association Between Age and PCI Effectiveness in Stable CAD: Secondary Analysis of ORBITA-2. (Journal of the American College of Cardiology) Article 3: Potent P2Y12 Inhibitor Monotherapy vs DAPT After PCI in Patients With and Without STEMI: The NEO-MINDSET Substudy. (Journal of the American College of Cardiology) Article 4: Early vs Late Staged PCI After Subintimal Tracking and Re-Entry for Chronic Total Occlusions: A Randomized Trial. (Journal of the American College of Cardiology) Article 5: Intracoronary Low-Dose Recombinant Tissue Plasminogen Activator in Primary PCI for ST-Segment Elevation Myocardial Infarction and Large Thrombus Burden: A Randomized Trial. (Journal of the American College of Cardiology) Full episode page: https://podcast.explainheart.com/podcast/tailoring-antiplatelets-after-p-c-i-for-a-c-s-01-29-26/ Featured Articles Article 1: Public Reporting and Case Selection in Congenital Heart Surgery: Signals From a Multicenter Observational Study. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41603821 Summary: This study investigated the association between public reporting and potential risk avoidance in congenital heart surgery. Researchers evaluated changes in case selection and hospital performance, using predicted probability of mortality as a measure of case-mix complexity. The work addressed the critical need to understand both changes in case selection and patient outcomes after public reporting, particularly concerning the potential for risk avoidance in complex surgical fields. Article 2: Association Between Age and PCI Effectiveness in Stable CAD: Secondary Analysis of ORBITA-2. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41603507 Summary: C. I. Effectiveness in Stable C. A. D.: Secondary Analysis of O. R. B. I. T. A. -2. The O. R. B. I. T. A. -2 trial demonstrated the efficacy of percutaneous coronary intervention in patients with stable angina and coronary artery disease, even without background antianginal medication. This secondary analysis specifically examined whether this percutaneous coronary intervention effect is consistent across different age groups. It focused on the interaction between age and both symptom relief and stenosis improvement, addressing a knowledge gap regarding treatment consistency across demographics. Article 3: Potent P2Y12 Inhibitor Monotherapy vs DAPT After PCI in Patients With and Without STEMI: The NEO-MINDSET Substudy. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41384891 Summary: A. P. T. After P. C. I. in Patients With and Without S. T. E. M. I.: The N. E. O. -M. I. N. D. S. E. T. Substudy. This prespecified analysis from the N. E. O. -M. I. N. D. S. E. T. trial evaluated whether treatment effects of early aspirin discontinuation differ between S. T. -segment elevation myocardial infarction and non-S. T. -segment elevation acute coronary syndrome. The study compared potent P2Y12 inhibitor monotherapy with dual antiplatelet therapy after percutaneous coronary intervention. This research addressed how acute coronary syndrome presentation influences optimal antiplatelet strategies post-percutaneous coronary intervention. Article 4: Early vs Late Staged PCI After Subintimal Tracking and Re-Entry for Chronic Total Occlusions: A Randomized Trial. Journal: Journal of the American College of Cardiology PubMed Link:...

Welcome to Cardiology Today – Recorded January 28, 2026. This episode summarizes 4 key cardiology studies on topics like Medicare beneficiaries and ozone. Key takeaway: Echocardiogram Predicts Pediatric E C M O Weaning. Article Links: Article 1: Widespread use of low efficacy antihypertensive regimens for the initial treatment of hypertension among older US adults. (American journal of hypertension) Article 2: Geographic patterns in critical CHDs: a spatial analysis of selected air pollutants. (Cardiology in the young) Article 3: Echocardiographic predictors of successful weaning from extracorporeal membrane oxygenation in paediatric and CHD patients with cardiogenic shock. (Cardiology in the young) Article 4: Patent ductus arteriosus status and treatment response alters myocardial adaptation in preterm infants. (Cardiology in the young) Full episode page: https://podcast.explainheart.com/podcast/echocardiogram-predicts-pediatric-e-c-m-o-weaning-01-28-26/ Featured Articles Article 1: Widespread use of low efficacy antihypertensive regimens for the initial treatment of hypertension among older US adults. Journal: American journal of hypertension PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41581126 Summary: The study found widespread use of low efficacy antihypertensive regimens for the initial treatment of hypertension among older United States adults. Analysis of a 20 percent random sample of Medicare beneficiaries aged 65 years and older with a hypertension diagnosis revealed that most patients remained on their initial treatment. This persistence on initial therapy occurred even when their blood pressure remained high, highlighting a significant challenge in effective blood pressure management for this population. The findings suggest a need to re-evaluate initial prescribing practices to improve patient outcomes. Article 2: Geographic patterns in critical CHDs: a spatial analysis of selected air pollutants. Journal: Cardiology in the young PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41582861 Summary: This retrospective study spatially analyzed critical congenital heart diseases in relation to selected air pollutants, focusing on geographic patterns. Researchers investigated 1484 infants who underwent complex cardiac surgery between 1996 and 2021. The study examined the association between critical congenital heart disease categories and maternal exposure levels during early pregnancy to nitrogen dioxide, ozone, and fine particulate matter. This work highlights the importance of environmental factors in understanding the incidence and distribution of congenital heart disease. Article 3: Echocardiographic predictors of successful weaning from extracorporeal membrane oxygenation in paediatric and CHD patients with cardiogenic shock. Journal: Cardiology in the young PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41582852 Summary: The study identified echocardiographic predictors for successful weaning from extracorporeal membrane oxygenation in pediatric and congenital heart disease patients experiencing cardiogenic shock. Researchers retrospectively analyzed patients who underwent venoarterial extracorporeal membrane oxygenation between March 2018 and September 2023. The comparison of clinical and echocardiographic variables at the time of weaning evaluation revealed key indicators differentiating successful from unsuccessful weaning. These findings offer crucial guidance for optimizing clinical decision-making during extracorporeal membrane oxygenation discontinuation. Article 4: Patent ductus arteriosus status and treatment response alters myocardial adaptation in preterm infants. Journal: Cardiology in the young PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41582772 Summary: The study found that patent ductus arteriosus status and treatment response significantly altered myocardial adaptation in preterm infants. This prospective cohort study compared serial echocardiographic trajectories across three...