Health Newsfeed – Johns Hopkins Medicine Podcasts

The good news is heart failure in people with severe obesity may be reversible with common weight loss drugs. The bad news is both obesity, with BMIs of around 30, and severe obesity, with a BMI of 42 or greater, … Increasing rates of obesity and severe obesity may presage increased rates of heart failure, Elizabeth Tracey reports Read More »

GLP-1 receptor agonists are effective in helping most people lose weight, and now a new study suggests that in those with severe obesity, a BMI of 42 or greater and who have a type of heart failure, this condition may … Is there another benefit besides weight loss of GLP-1s in people with severe obesity? Elizabeth Tracey reports Read More »

There’s a relationship between severe obesity and one type of heart failure, and it looks like it’s mediated by adding more phosphate groups, a process known as phosphorylation, to proteins in heart muscle cells, specifically to units within the muscle … Can GLP-1 agonists help in heart failure and severe obesity? Elizabeth Tracey reports Read More »

Severe obesity may impede the ability of units inside heart muscle cells called sarcomeres to contract, and losing weight may reverse that condition. That’s according to research by cardiologist David Kass and colleagues at Johns Hopkins, who looked closely at … What is severe obesity doing to the heart muscle’s ability to contract? Elizabeth Tracey reports Read More »

Heart failure with preserved ejection fraction, so-called HFpEF, is happening more frequently, especially in those with severe obesity. David Kass, a cardiologist and researcher at Johns Hopkins, and colleagues, have looked closely at heart muscle cells from this group of … How is obesity related to a common form of heart failure? Elizabeth Tracey reports Read More »

Brain organoids, collections of cells found in the brain, have been grown from blood samples of people with Alzheimer’s disease and used to assess the impact of a drug called escitalopram in a new study. Vasiliki Machairaki, study leader and … A model of your brain may one day be grown in a lab, Elizabeth Tracey reports Read More »

Extracellular vesicles are membrane bound packages cells use to jettison materials from inside the cell, a sort of trash can. Johns Hopkins genetic medicine expert Vasiliki Machairaki has shown in a new study that these vesicles may be a means … What can be learned from what cells dispose of? Elizabeth Tracey reports Read More »

What might a model of the hindbrain, which helps control functions like sleep, breathing and heart rate, tell us about using a common depression drug in people with Alzheimer’s disease? Genetic medicine expert Vasiliki Machairaki at Johns Hopkins says her … Brain organoids can resemble specific parts of the brain, Elizabeth Tracey reports Read More »

Drugs to manage symptoms of Alzheimer’s disease may work in some people but not in others. Now a new method using brain organoids, which are derived from a person’s own blood sample, may help determine whether a specific medication is … Can drugs to manage Alzheimer’s disease be tested in organoids? Elizabeth Tracey reports Read More »

Brain organoids are lab grown clusters of cells that have several of the cell types found in someone’s brain. Cells taken from a person’s blood are coaxed to become stem cells, then differentiate into brain cells. Vasiliki Machairaki, a genetic … Can brain organoids help in treating people with Alzheimer’s disease? Elizabeth Tracey reports Read More »

Medicaid reductions being rolled out this year are poised to dramatically reduce cancer screening for millions, a new study estimates. William Nelson, director of the Kimmel Cancer Center at Johns Hopkins, takes a look at the numbers. Nelson: This is … Medicaid reductions may impact screening for cancer, Elizabeth Tracey reports Read More »

Breast cancer screening is associated with false positives, where women are referred for further assessments and procedures that may be unnecessary. Does it help to stratify women based on risk factors like genetics before they have screening? Johns Hopkins Kimmel … Should breast cancer screening be targeted to those at greatest risk? Elizabeth Tracey reports Read More »

People who were older and had advanced cancers benefited from a telephone-based intervention designed to regularly assess their symptoms and refer them to expert clinicians, by reducing their visits to emergency departments and need for hospitalization. Kimmel Cancer Center director … Can older people with cancer benefit from telephone based contact? Elizabeth Tracey reports Read More »

Seventy percent of people diagnosed with cancer in the United States will still be alive five years later, the American Cancer Society reports. William Nelson, director of the Kimmel Cancer Center at Johns Hopkins, says yes, and. Nelson: There's still … Good news on cancer survival! Elizabeth Tracey reports Read More »

American Cancer Society data find that the majority of people who are diagnosed with cancers of all types will still be alive five years later. Johns Hopkins Kimmel Cancer Center director William Nelson says this is good news indeed. Nelson: … There’s good news regarding survival when cancer if found, Elizabeth Tracey reports Read More »

PICS stands for post intensive care syndrome, and it is characterized by a number of physical and mental health conditions that may follow someone’s stay in an ICU. Rohan Mathur, a critical care expert at Johns Hopkins, says fatigue, memory … Who is at risk to develop PICS? Elizabeth Tracey reports Read More »

Physical and mental health issues can follow a stay in an intensive care unit, a condition known as PICS, for post intensive care syndrome. Rohan Mathur, a critical care expert at Johns Hopkins, says now that more attention is being … What can be done about PICS? Elizabeth Tracey reports Read More »

When someone has survived an intensive care unit stay, they may experience a host of challenges to their wellbeing known collectively as post intensive care syndrome, or PICS. Critical care expert Rohan Mathur at Johns Hopkins says sometimes the worst … How can you tell if PICS is present? Elizabeth Tracey reports Read More »

PICS stands for post intensive care syndrome, and recent data indicate that perhaps the majority of people who’ve been hospitalized in an ICU will have what are called sequelae, or lingering issues once they’re stepped down or discharged. Johns Hopkins … What kinds of issues may remain after someone has been in an intensive care unit? Elizabeth Tracey reports Read More »