The Science of Skin

In this clinically rich episode, host Dr. Ted Lain sits down with board-certified dermatologist and global skin cancer expert Dr. Todd Schlesinger — AAD Board of Directors member, Mohs surgeon, clinical assistant professor at George Washington University School of Medicine, and medical director of the Clinical Research Center of the Carolinas — for a deep dive into systemic and targeted therapies for non-melanoma skin cancer (NMSC). The doctors begin with a thorough breakdown of the hedgehog signaling pathway (PATCHED, Smoothened, GLI-1 transcription) and how mutations in this pathway drive basal cell carcinoma (BCC) growth. They compare the two FDA-approved hedgehog pathway inhibitors (HHIs) — vismodegib (Erivedge) and sonidegib (Odomzo) — covering their mechanisms of action, volume of distribution differences (16–18L vs. ~9,000L), indications for locally advanced and metastatic BCC, how to define "locally advanced," and complete vs. partial response rates. Dosing strategies are addressed in detail, including alternate-day dosing and treatment breaks backed by the MIKIE study and STEVIE safety study. For managing the most common adverse events — muscle cramps, dysgeusia, weight loss, and fatigue — Dr. Schlesinger shares his clinical protocol using L-carnitine supplementation (1,500–2,000mg liquid, started 2–4 weeks before therapy) along with calcium and CoQ10. The conversation then moves to PD-1 and PD-L1 checkpoint inhibitors for locally advanced and metastatic cutaneous squamous cell carcinoma (cSCC) and BCC, covering cemiplimab (Libtayo), pembrolizumab (Keytruda), and nivolumab (Opdivo). The hosts explain the immune checkpoint mechanism using a memorable analogy, discuss how UV exposure upregulates PD-1 on tumor cells, and explore the practical realities of dermatologists prescribing infusion-based immunotherapy — including multidisciplinary care team logistics, buy-and-bill considerations, and when to partner with oncology. The episode closes with an exciting look at the pipeline: intralesional therapies for nodular and superficial BCC from companies including Verica, iViva, PHIO, and Feldan, red light PDT for superficial BCC nearing FDA approval, and the broader question of where these drugs fit as neoadjuvant, adjuvant, or primary therapies — and what complete response benchmarks (80–95%) dermatologists should expect before adopting non-surgical primary options. DISCLAIMER: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

Acne doesn't end when the breakout does — and this episode is all about treating the full journey. In this special Neutrogena-sponsored episode of the Science of Skin podcast, board-certified dermatologists Dr. Ted Lain and Dr. Patti Farris sit down with Rabab Hussain, PharmD, RPh. from Neutrogena's Translational Science team to break down the brand-new Evenly Clear acne line — a dermatologist-informed collection designed to tackle both active acne and post-inflammatory hyperpigmentation (PIH) in one cohesive regimen. Together, they dive deep into the science behind each product, including: Evenly Clear Acne CleanserEvenly Clear Acne Gel MoisturizerEvenly Clear Acne Cleansing MaskEvenly Clear RetinoidEvenly Clear Acne ExfoliantEvenly Clear Clarifying Spray Whether you're treating teens, adult women with hormonal acne, or patients with skin of color concerned about dark marks, this episode gives you the clinical rationale to confidently recommend OTC options — no prior authorization required. Topics covered: acne treatment regimens, post-inflammatory hyperpigmentation, skin barrier repair, the skin microbiome and dysbiosis, retinoids OTC, chemical exfoliants, hypochlorous acid, benzoyl peroxide tolerability, and building a complete acne skincare routine. Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

The skincare conversation is shifting — and dermatology is leading the charge. In this episode, we dive deep into the emerging world of skin longevity, exploring why the industry is moving away from "anti-aging" and embracing a bold new pro-aging philosophy that celebrates long-term skin health over surface-level fixes. We break down what the groundbreaking Science of Skin Longevity Summit means for dermatologists, skincare professionals, and consumers alike — and why the skin is being recognized as the body's hallmark longevity organ. From longevity cosmeceuticals and cutting-edge procedures like microneedling and dermal fillers, to the complex, personalized science of measuring skin health over time, this episode covers it all. We also explore how artificial intelligence is poised to revolutionize personalized longevity skincare, and why collaboration between dermatologists and the cosmetic industry is no longer optional — it's essential. Whether you're a skincare enthusiast, a medical professional, or simply someone who wants to age with intention, this episode will change the way you think about your skin — for life. In this episode, you'll learn: 🌐 For more information, visit: scienceofskinsummit.com/longevity See omnystudio.com/listener for privacy information.

In this episode of the Science of Skin Podcast, board-certified dermatologist Dr. Ted Lain sits down with world-renowned eczema and atopic dermatitis expert Dr. Peter Lio, founder of the Chicago Integrative Eczema Center, to unpack a game-changing shift in how dermatologists think about chronic inflammatory skin conditions. If you're a dermatologist, skincare professional, or someone managing eczema, psoriasis, seborrheic dermatitis, or other steroid-responsive skin conditions — this episode is essential listening. What you'll learn: topical steroid withdrawal (TSW)PDE4 (phosphodiesterase 4)PDE4 inhibitor topical therapiesroflumilast (Zoryve)"PDE4 inhibitor-responsive dermatoses"JAADzero FDA-approved treatmentssafety profileinnovation in topical therapies Featured guest: Dr. Peter Lio, MD — Clinical Assistant Professor of Dermatology and Pediatrics, Northwestern University; Founder, Chicago Integrative Eczema Center; Global speaker, researcher, and consultant in atopic dermatitis and inflammatory skin disease. Sponsored by Arcutis Biotherapeutics, makers of roflumilast (Zoryve) topical foam and cream. This episode was recorded ahead of the 2026 AAD Annual Meeting. Link to Dr. Lio's JAAD publication on PDE4 inhibitor-responsive dermatoses. DISCLAIMER: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment See omnystudio.com/listener for privacy information.

What is Hidradenitis Suppurativa (HS), and how is it treated? In this episode of the Science of Skin podcast, dermatologist Dr. Ted Lain is joined by HS specialist Dr. Steve Daveluy to break down everything you need to know about this chronic inflammatory skin disease — from early diagnosis to cutting-edge treatments. In this episode, we cover: Whether you're a dermatologist, healthcare provider, or someone personally affected by Hidradenitis Suppurativa, this episode offers expert insight into the latest research, treatment strategies, and the future of HS care. 🎙️ Subscribe to the Science of Skin podcast for the latest in dermatology, skincare science, and clinical breakthroughs. DISCLAIMER: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

What does it take to lead the most powerful dermatology organization in the world? In this inspiring episode of The Science of Skin podcast, host Dr. Patti Farris sits down with outgoing American Academy of Dermatology (AAD) President Dr. Susan Taylor for a candid look at her landmark year at the helm. Dr. Taylor shares how she fought for Medicare physician payment reform on Capitol Hill, tackled scope of practice battles across the country, and launched the widely successful "Your Dermatologist Knows" public education campaign — all while championing women in medicine and leadership. She also gets personal about the invisible "second shift" burden professional women carry at home and why delegation is leadership — a mindset that is transforming the lives of physicians everywhere. From AI in dermatology to unifying a diverse specialty, Dr. Taylor offers a powerful and practical vision for the future of skin care and medicine. A must-listen for dermatologists, medical professionals, and anyone passionate about skin health, advocacy, and breaking barriers in medicine. See omnystudio.com/listener for privacy information.

What does it really take to build a skincare-forward aesthetic practice — and why does it matter more than ever? In this episode of the Science of Skin podcast, board-certified dermatologists Dr. Patti Farris and Dr. Ruth Tedaldi break down how practitioners can seamlessly integrate medical-grade skincare into cosmetic consultations, streamline office workflows, and empower staff to become confident skincare educators. The conversation goes beyond the basics, diving into how to evaluate and select the right skincare products, why science-backed knowledge is the foundation of effective recommendations, and how a longevity-focused mindset is reshaping the future of skin health. Dr. Farris and Dr. Tedaldi also explore one of the most talked-about breakthroughs in aesthetic dermatology — exosomes — unpacking the clinical science behind their growing role in skincare treatments and the results practitioners are seeing firsthand. They spotlight innovations in hair restoration, including the science behind Rion's hair serum, and take an honest look at the rise of digital sales platforms in the professional skincare space, including their own venture, Regimen Pro. Whether you're a dermatologist, aesthetician, or skincare professional looking to elevate your practice and better serve your patients, this episode delivers the clinical insights and practical strategies you need to stay ahead. Topics covered: medical-grade skincare, aesthetic dermatology, cosmetic consultations, skincare education, exosomes, hair restoration, longevity skincare, Regimen Pro, professional skincare recommendations, office workflow optimization Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

In this episode of the Science of Skin podcast, Dr. Patti Farris and Dr. Ted Lain explore the history and significance of Cetaphil, a legendary brand in dermatology. They discuss the origins of its key ingredient, Cetal alcohol, and its role in skincare formulations, particularly for sensitive skin. The conversation highlights the brand's evolution, including recent reformulations that enhance its effectiveness while addressing modern skincare needs. The hosts emphasize the importance of barrier function and the impact of inflammation on skin health, particularly for patients with sensitive skin. They also preview future discussions on the science behind Cetaphil products. Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

In this episode of The Science of Skin, Dr. Elke Grönniger from Beiersdorf discusses her research on epigenetics and cellular rejuvenation, focusing on dehydromyricetin's role in demethylating the epigenome. The conversation highlights the shift towards preventative skincare, targeting the root causes of aging, and the importance of understanding the hallmarks of aging for future product development. Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

In this episode of the Science of Skin podcast, Dr. Ted Lain interviews Dr. Hassan Galadari, a renowned dermatologist from Dubai. They discuss the journey of hosting the World Congress of Dermatology, the evolution of injectables in aesthetic medicine, and the significance of polynucleotides and PDRN in skin rejuvenation. The conversation also touches on the role of epigenetics in longevity and the unique experience of practicing dermatology in Dubai, a city known for its diverse population and rapid development. Takeaways Dr. Galadari is a leader in injectables and aesthetic dermatology. Hosting the World Congress requires international support and persistence. Injectables are shifting towards biostimulatory fillers for natural results. Polynucleotides and PDRN have unique mechanisms in skin rejuvenation. Inflammation plays a significant role in the aging process. GLP-1s may enhance skin quality while reducing inflammation. Dubai's diverse population enriches the practice of dermatology. International conferences foster valuable connections and knowledge exchange. Longevity in dermatology involves optimizing cellular function. The aging process requires a multifaceted approach to treatment. Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

In this milestone 100th episode of the Science of Skin podcast, Dr. Ted Lain and Dr. Patti Farris reflect on their journey, discussing impactful studies in dermatology, the importance of skincare for menopause, the definition of skin quality, and the integration of Eastern and Western medicine. They also explore the gut-skin connection, the issue of human trafficking in dermatology, and highlight pioneers in the field. The episode concludes with insights into the business of skincare and a heartfelt thank you to their loyal listeners. Takeaways This is episode number 100 for the science of skin podcast. We have a very loyal following. The antioxidant study debunked previous misconceptions. C.E. Ferulic remains foundational in skincare. The sandwich technique affects retinoid efficacy. HRT is crucial for managing menopause symptoms. Skin quality metrics are essential for patient satisfaction. Integrating Eastern medicine can enhance treatment outcomes. The gut-skin connection is scientifically supported. Human trafficking awareness is vital for dermatologists. DISCLAIMER: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

Dr. Ted Lain sits down with Tom Allison to uncover the origin story of CeraVe—from its pharmaceutical roots to becoming one of the most dermatologist-recommended skincare brands in the world. They explore the science behind ceramides and MVE technology, the role of dermatologists in product development, and key lessons in building a brand that truly serves patients. A must-listen for clinicians, skincare professionals, and anyone curious about the intersection of science, skin health, and smart business. To watch this and other episodes, be sure to check out our YouTube page Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

In honor of the start of Black History Month, Dr. Patti Farris and Dr. Heather Woolery-Lloyd delve into the complexities of hair care for textured hair. They discuss the historical significance of Madam C.J. Walker, the physiological differences in hair types, and the unique hair care routines required for textured hair. The conversation also covers the risks of over-processing, the importance of finding the right stylist, and the challenges of conditions like traction alopecia and CCCA. Additionally, they address recent studies linking hair treatments to cancer, emphasizing the need for careful interpretation of research findings. Takeaways Madam C.J. Walker was a pioneer in hair care marketing. Textured hair has unique physiological characteristics. Washing textured hair should be done every one to two weeks. Heat can cause significant damage to textured hair. Finding a knowledgeable stylist is crucial for hair health. Traction alopecia is a common issue in textured hair. CCCA can be treated effectively if caught early. Shampoo choices should be personalized for textured hair. Recent studies on hair treatments and cancer need careful interpretation. Education on textured hair care is essential for dermatologists. DISCLAIMER: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

In this episode of the Science of Skin podcast, Dr. Ted Lain interviews Dr. Matt Zirwas, a leading expert in dermatology, focusing on the latest advancements in treatments for atopic dermatitis and psoriasis. They discuss the potential of new drugs targeting the OX40 pathway, innovative drug delivery methods, and the emergence of highly effective oral therapies for psoriasis. The conversation highlights the evolving landscape of dermatological treatments and the exciting prospects for long-term patient outcomes. In this conversation, Dr. Zirwas and Dr. Lain discuss various dermatological treatments, focusing on drug administration, bioavailability, and the efficacy of new medications for conditions like hidradenitis suppurativa and chronic spontaneous urticaria. They explore the implications of PDE4 inhibitors, the challenges of assessing treatment outcomes, and the importance of pain management in patient care. The discussion highlights the evolving landscape of dermatology and the significance of clinical trials in advancing treatment options. To watch this and other episodes, be sure to check out our YouTube page Takeaways: New drugs targeting the OX40 pathway may revolutionize treatment for atopic dermatitis. Innovative drug delivery methods could lead to less frequent dosing for patients. The potential for long-term remission in atopic dermatitis is an exciting prospect. Adverse events in new drugs may correlate with better efficacy. Oral therapies for psoriasis are emerging as a new class of effective treatments. The efficacy of new oral drugs may surpass traditional biologics. The importance of understanding pharmacokinetics in drug efficacy is highlighted. The development of advanced systemic therapies is changing the landscape of dermatology. The future of psoriasis treatment may include drugs that effectively target both skin and joint disease. Drug bioavailability is significantly affected by food intake. PDE4 inhibitors show promise in improving various conditions. Cognitive benefits have been observed with PDE4 inhibitors. Pain management is a critical endpoint in HS treatment. Assessing HS severity is challenging for investigators. New treatments are emerging for chronic spontaneous urticaria. Patient satisfaction is essential in evaluating treatment success. Innovative drugs are changing the landscape of dermatology. Clinical trials are crucial for advancing treatment options. Understanding patient needs is key to effective care. Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

In this episode of the Science of Skin podcast, Dr. Ted Lane and Dr. Patty Ferris discuss emerging skincare trends for 2026, while also reflecting on practices from 2025 that they hope will fade away. They express their disdain for certain ingredients like beef tallow and complicated skincare regimens, advocating instead for simplicity and effectiveness in skincare routines. The conversation shifts to the rise of regenerative ingredients and the importance of personalized skincare, emphasizing the need for dermatologists to remain integral in skincare consultations despite the growing influence of AI in the field. The hosts delve into the advancements in sunscreen technology, particularly a new UVA filter expected to be approved soon, and the potential for DNA repair innovations in skincare. They also touch on the increasing importance of supplements in skincare, the impact of hormonal changes on skin health, and the need for education around teenage skincare. The episode concludes with a call for dermatologists to embrace their role as skincare experts, ensuring patients receive the best advice amidst the overwhelming information available online. To watch this an other episodes, be sure to check out our YouTube page Takeaways Out with the complicated, in with the curated. Don't underestimate the value of a dermatologist consultation. Regenerative ingredients can reverse skin damage. 2026 will see a rise in personalized skincare. The microbiome plays a crucial role in skin health. Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

Dr. Patti Farris sits down with Brit Fallon from NewBeauty Magazine. They discuss the influence of social media on skincare, the distinction between skincare and dermfluencers, the ethical role of board-certified dermatologists, and emerging trends like regenerative skincare and AI in personalized beauty. To watch this an other episodes, be sure to check out our YouTube page Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

Dr. Patti Farris hosts Sarika Diaz and Renee Rouleau to discuss their roles at the Science of Skin Summit 2025. They highlight the importance of community, relationships, and education in skincare, particularly regarding acne management and the collaborative efforts between estheticians and physicians for effective treatment and advanced services. To watch this an other episodes, be sure to check out our YouTube page Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

In this episode of the Science of Skin podcast, Dr. Ted Lain and Dr. Andrew Alexis discuss Triferatine Cream, a novel fourth-generation retinoid. They explore its mechanism of action, clinical efficacy, and the importance of addressing not only acne lesions but also the psychosocial impacts of acne on patients. The conversation delves into the results of phase three and phase four clinical trials, highlighting Triferatine's effectiveness in treating both acne and post-inflammatory hyperpigmentation. The episode emphasizes the need for dermatologists to consider the entire acne journey and the long-term benefits of retinoid therapy for their patients. To watch this an other episodes, be sure to check out our YouTube page Takeaways: Triferatine is a novel fourth-generation retinoid. It binds preferentially to the RAR gamma receptor, enhancing its efficacy. Triferatine not only treats acne but also improves scarring and pigmentation. Clinical trials show significant efficacy in both facial and truncal acne. The psychosocial impact of acne is profound and long-lasting. Retinoids are foundational in acne treatment regimens. Patients benefit from continued use of retinoids beyond acne clearance. Phase four studies demonstrate Triferatine's effectiveness in reducing atrophic scars. Acne-induced hyperpigmentation is a significant concern that needs addressing. Education about retinoids can improve patient compliance. See omnystudio.com/listener for privacy information.

In this episode of the Science of Skin podcast, Dr. Ted Lain interviews Dr. Scott Drew, a dermatologist and philanthropist, about his work with the Power of a Nickel, a nonprofit organization dedicated to providing healthcare to underserved populations around the world. They discuss the mission of the organization, the cultural challenges faced during medical missions, the importance of continuity of care, and the logistics of organizing these trips. Dr. Drew shares personal anecdotes and insights from his experiences, emphasizing the need for open-mindedness and cultural sensitivity in global health initiatives. To learn more about Power of a Nickel, please click the link: https://powerofanickel.org/ To watch this an other episodes, be sure to check out our YouTube page Takeaways The Power of a Nickel focuses on providing healthcare to underserved populations. Cultural understanding is crucial when practicing medicine in different countries. Medical students gain invaluable experience through international missions. Dermatology often addresses common health issues exacerbated by lack of resources. Volunteers do not need specialized training but should be open-minded. Continuity of care is essential for effective healthcare delivery. Living conditions during medical missions can vary significantly. Volunteers are provided with necessary supplies and support. Community engagement is key to successful healthcare initiatives. The organization fosters a multidisciplinary approach to healthcare. Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.

In this episode, Dr. Patti Farris and Dr. Ted Lain discuss their experiences at the A4M Longevity Fest in Las Vegas, highlighting the growing interest in anti-aging medicine and longevity. They delve into various topics including female health, hormonal balance, the importance of exercise and muscle mass, innovations in personalized medicine, the microbiome's role in aging, the rise of peptides, and nutritional insights for longevity. The conversation also covers emerging technologies and products seen at the exhibit hall, concluding with a look at the future of longevity medicine. To watch this an other episodes, be sure to check out our YouTube page Takeaways The A4M Longevity Fest showcased a significant interest in anti-aging medicine. Female longevity and hormonal health are critical areas of focus. Exercise and maintaining muscle mass are essential for longevity. Personalized medicine is evolving with advancements in epigenetics. The microbiome plays a crucial role in aging and health. Peptides are gaining traction in longevity treatments. Nutrition, particularly protein intake, is vital for long-term health. The exhibit hall featured numerous innovative products and technologies. Liquid biopsies are becoming a mainstream tool for early detection. Longevity medicine is increasingly becoming a part of mainstream healthcare. Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment. See omnystudio.com/listener for privacy information.